OPG tsim tawm nyob qhov twg?

Video: OPG tsim tawm nyob qhov twg?

2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44

Cov tshuaj Osteoprotegerin ( OPG ) yog zais los ntawm osteoblasts thiab osteogenic stromal qia hlwb thiab tiv thaiv lub cev pob txha los ntawm ntau pob txha resorption los ntawm kev khi rau RANKL thiab tiv thaiv nws los ntawm kev cuam tshuam nrog RANK. RANKL/ UA OPG piv hauv cov pob txha yog li yog qhov tseem ceeb txiav txim siab ntawm pob txha loj hauv ib txwm thiab kab mob xeev.

Yog li ntawd, qhov twg yog qeb tsim tawm?

RANKL tshwm sim los ua homotrimeric protein thiab feem ntau yog daim nyias nyias-khi ntawm osteoblastic thiab qhib T cells lossis raug zais los ntawm qee lub cell, xws li qhib T cells (43-45). Cov protein zais cia tau muab los ntawm daim nyias nyias ua los ntawm kev tiv thaiv kab mob proteolytic lossis lwm txoj kev sib txuas (46).

RANK ligand tsim tawm li cas? Marrow stromal thiab osteoblastic cells tsim RANKL , thiab kev tswj hwm ntawm nws cov mRNA tau pom los cuam tshuam nrog kev ua haujlwm ntawm osteoclastogenesis. Receptor rau RANKL yog RANK . Zoo li OPG, RANK yog TNF tus neeg txais khoom superfamily tam sim no ntawm osteoclast cov txheej txheem ua ntej thiab cov osteoclasts paub tab.

Kuj nug, qhov twg yog rankl?

Cov nqaij nthuav qhia Cov protein ntau qhia ntawm RANKL feem ntau kuaj pom hauv lub ntsws, thymus thiab qog ntshav. Cov protein qis qhia pom nyob hauv cov pob txha pob txha, lub plab, cov hlab ntshav sab hauv, tus po, tus tso me nyuam, leukocytes, lub plawv, cov thyroid, thiab cov leeg pob txha.

Rankl sawv rau dab tsi?

RANK yog tus txais rau RANK-Ligand ( RANKL ) thiab ib feem ntawm RANK/ RANKL /OPG teeb tsa txoj hauv kev uas tswj hwm kev sib txawv ntawm osteoclast thiab ua kom muaj zog. Nws yog cuam tshuam nrog kev txhim kho pob txha thiab kho, kev ua haujlwm ntawm lub cev tiv thaiv kab mob, kev txhim kho cov qog ntshav, kev tswj hwm cua sov, thiab kev txhim kho qog noj ntshav.

Pom zoo:

Qhov chaw nyob ntawm thawj lub tsev kawm qib siab kho hniav nyob hauv ntiaj teb nyob qhov twg?

Dr. John M. Harris tau pib lub ntiaj teb thawj lub tsev kho hniav hauv Bainbridge, Ohio, thiab tau pab tsim kho hniav raws li kev noj qab haus huv. Nws qhib rau 21 Lub Ob Hlis 1828, thiab niaj hnub no yog tsev khaws puav pheej kho hniav. Thawj lub tsev kawm kho hniav, Baltimore College ntawm Kev Kho Hniav, tau qhib hauv Baltimore, Maryland, Asmeskas xyoo 1840

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Thaum ib tus tswv ntiav haujlwm tau txais OSHA qhov kev hais tawm Qhov twg lawv yuav tsum tshaj tawm daim ntawv theej ntawm qhov kev hais tawm?

Yuav Tsum Tau Xa Ntawv Thaum koj tau txais OSHA Daim Ntawv Ceeb Toom, koj yuav tsum tshaj tawm nws (lossis daim ntawv theej ntawm nws) ntawm lossis ze qhov chaw uas txhua qhov kev ua txhaum tshwm sim los ua rau cov neeg ua haujlwm paub txog qhov phom sij uas lawv yuav raug nthuav tawm. Tsab ntawv ceeb toom OSHA yuav tsum tau tshaj tawm rau 3 hnub ua haujlwm lossis kom txog thaum qhov kev phom sij raug txo, qhov twg yog qhov ntev dua

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