Video: Endotoxin ua rau mob septic poob siab li cas?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Septic poob siab tshwm sim thaum kis mob hnyav nrog cov kab mob Gram-negative thaum cov kab mob lossis lipopolysaccharide nkag mus rau hauv cov hlab ntshav. Endotoxin ua rau neutrophils, platelets thiab ntxiv rau tsim, ob qho tib si ncaj qha thiab los ntawm mast cell degranulation, vasoactive amines uas ua mob hypotension.
Tom qab ntawd, ib tus tseem tuaj yeem nug, endotoxins thiab septic shock yog dab tsi?
Endotoxin yog a lipopolysaccharide (LPS) nyob rau sab nrauv ntawm cov kab mob gram-negative. Tshaj 60 xyoo dhau los, cov kws tshawb fawb tau muab endotoxin rau tsiaj thiab tib neeg tuaj yeem pab dawb septic poob siab thiab tshawb xyuas cov xwm txheej pathophysiologic cuam tshuam nrog Syndrome no [1, 2].
Ib qho ntxiv, cov kab mob dab tsi feem ntau ua rau mob septic poob siab? Cov feem ntau ntau ua ntawm sepsis hauv pab pawg hnub nyoog suav nrog Streptococcus pneumoniae, Neisseria meningitidis, thiab Staphylococcus aureus.
Kuj paub yog, puas tuaj yeem ua rau endotoxin ua rau poob siab?
Endotoxins (lipopolysaccharide, LPS) yog cov tshuaj lom neeg muaj nyob hauv cov kab mob Gram-negative. Kev txhaj tshuaj kom huv LPS rau hauv kev sim tsiaj coj mus rau kev txhim kho ntawm ntau yam kev ua haujlwm lom neeg uas tau coj mus rau poob siab nrog kev tuag ua ntej.
Dab tsi yog pathophysiology ntawm septic shock?
Pathophysiology . Cov pathophysiology ntawm septic shock tsis nkag siab kiag li, tab sis nws tau paub tias lub luag haujlwm tseem ceeb hauv kev txhim kho sepsis hnyav tau ua los ntawm kev tiv thaiv kab mob thiab coagulation teb rau tus kab mob. Septic poob siab koom nrog cov lus teb hnyav uas ua rau muaj cov txiaj ntsig hypermetabolic.
Pom zoo:
Qhov kev kho mob tsim nyog tshaj plaws rau kev poob siab hypovolemic yog dab tsi?
Kev tso kua dej rov qab yog lub hauv paus tseem ceeb ntawm kev kho mob rau cov neeg mob hypovolemia hnyav. Txawm hais tias tsis muaj lub ntsiab lus tseeb tshwm sim, cov mob hypovolemia hnyav tuaj yeem tshwm sim thaum poob ntshav lossis cov kua dej ntau ntxiv ua rau poob qis hauv lub cev
Puas yog kev tuag los ntawm septic poob siab?
Yog ntes tau ntxov, sepsis kho tau nrog kua thiab tshuaj tua kab mob. Tab sis nws vam meej sai thiab yog tias tsis kho, apatient tus mob tuaj yeem ua rau hnyav sepsis, nrog kev hloov pauv hauv kev puas siab puas ntsws, txo qis zis tawm, mob plab thiab ua pa nyuaj
Qhov kev pabcuam twg uas tus kws saib xyuas neeg mob siv ua ntej rau tus neeg mob metabolic acidosis los ntawm kev poob siab?
Cov kws saib xyuas mob twg uas siv thawj zaug rau tus neeg mob nrog metabolic acidosis los ntawm kev poob siab? Muab cov kua dej tso rau hauv. Tus kws saib xyuas neeg mob xav tias tus neeg mob tau tsim cov kab mob metabolic acidosis vim yog kev tsim tawm ntau dhau ntawm hydrogen ions
Vim li cas lub plawv tso zis siab nyob rau hauv septic poob siab?
Thaum xub thawj, cov hlab ntsha thiab cov hlab ntsha nthuav dav, ua rau cov hlab ntsha peripheral poob qis; cardiac tso zis feem ntau nce. Cov theem no tau raug xa mus rau qhov sov sov. Txawm hais tias nyob rau theem ntawm cov zis ntau zog, vasoactive mediators ua rau cov ntshav ntws los hla cov hlab ntsha capillary (ib qho cuam tshuam tsis zoo)
Thaum tus kws kho mob tau tso cai tso cai ntau npaum li cas yuav tsum muaj kev sib ntsib tim ntsej tim muag tshwm sim ntawm tus kws kho mob thiab cov kws kho mob qib siab uas tau sau npe rau tus nais maum?
Txawm li cas los xij, yog tias APRN lossis PA tau nyob hauv daim ntawv pom zoo tso cai nrog kws saib xyuas kws kho mob tsawg kawg tsib ntawm xya xyoo dhau los, cov rooj sib tham tim ntsej tim muag yuav tsum tshwm sim tsawg kawg ib hlis txog rau thawj hnub ntawm hnub uas tau pom zoo kos npe