Video: Tus tyrosine kinase inhibitor ua haujlwm li cas?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
A tyrosine kinase inhibitor (TKI) yog ib qho tshuaj yeeb tshuaj uas tiv thaiv tyrosine kinases . Tyrosine kinases yog enzymes ua lub luag haujlwm rau kev ua kom ntau cov protein los ntawm cov teeb liab hloov pauv. Cov protein yog qhib los ntawm kev ntxiv ib pawg phosphate rau cov protein (phosphorylation), ib qib uas TKIs txwv.
Ntawm no, dab tsi yog tyrosine kinase inhibitors siv rau?
Tyrosine kinases yog ib feem ntawm ntau txoj haujlwm ntawm tes, suav nrog kev xa xov tooj ntawm tes, kev loj hlob, thiab faib tawm. Cov enzymes no tuaj yeem ua haujlwm dhau los lossis pom nyob rau qib siab hauv qee hom qog nqaij hlav cancer, thiab thaiv lawv yuav pab ua kom cov qog nqaij hlav cancer loj tuaj. Ib txhia tyrosine kinase inhibitors yog siv rau kho mob qog noj ntshav.
tyrosine kinase receptors ua haujlwm li cas? Receptor tyrosine kinases (RTKs), uas khi rau peptide/cov tshuaj hormones, yuav muaj nyob li dimers lossis dimerize thaum khi rau ligands. Ligand kev khi ua rau ua kom muaj zog ntawm kinase ua kev ua ntawm tus txais thiab autophosphorylation ntawm tyrosine cov seem hauv nws cov npe cytosolic (saib Daim duab 20-31).
Tom qab ntawd, ua li cas kinase inhibitors ua haujlwm?
Cov protein kinase inhibitor . Cov protein kinase inhibitor yog ib hom enzyme inhibitor uas thaiv qhov kev txiav txim ntawm ib lossis ntau cov protein cov kinases . Cov protein cov kinases yog cov enzymes uas ntxiv phosphate (PO4) pab pawg rau cov protein, thiab tuaj yeem hloov kho nws txoj haujlwm.
Cov kev mob tshwm sim ntawm tyrosine kinase inhibitors yog dab tsi?
- Xeev siab thiab ntuav.
- Raws plab.
- Pob khaus.
- Mob taub hau.
- Qaug zog.
- Cov ntshav ntshav qis dua.
Pom zoo:
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