Video: Dab tsi yog c3a thiab c5a?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
C3a thiab C5a , qhov me me (kwv yees li 10KDa) qhov tawg tawg tawm los ntawm kev ua kom tiav, yog cov kws kho mob muaj zog ntawm kev mob. Lawv yog cov tshuaj anaphylatoxins thiab ua lub cell activators nrog nanomolar affinity, ua haujlwm lawv los ntawm kev khi rau cov neeg txais tshwj xeeb (C3aR thiab C5aR lossis C5L2 feem).
Tom qab ntawd, ib tus tseem tuaj yeem nug, c3a ua haujlwm li cas?
C3a yog ib qho ntawm cov proteins uas tsim los ntawm cleavage ntawm complement 3; lwm tus yog C3b. C3a yog qhov cuam tshuam ntawm kev ua tiav nrog ntau yam ntawm kev ua haujlwm suav nrog T cell ua kom muaj sia nyob thiab muaj sia nyob, stimulation angiogenesis, chemotaxis, mast cell degranulation, thiab macrophage activation.
c3a yog cytokine? C3a thiab C5a anaphylatoxins yog cytokine cov -lub polypeptides tsim thaum lub sijhawm ua tiav (C) kev ua haujlwm thiab tso tawm ntawm qhov chaw mob. Lawv siv ntau yam kev ua ub no los ntawm kev khi rau G-protein-coupled receptors C3aR thiab C5aR, feem.
Anaphylatoxins ua dab tsi?
Anaphylatoxin . C3a, C4a thiab C5a cov khoom yog raug xa mus ua anaphylatoxins : lawv ua rau cov leeg nqaij du, vasodilation, histamine tso tawm los ntawm mast hlwb, thiab txhim kho vascular permeability. Lawv kuj tseem kho cov tshuaj chemotaxis, mob o, thiab tsim cov tshuaj cytotoxic oxygen radicals.
Puas yog c5a yog chemokine?
Cov protein no yog tsim los ntawm alpha thiab beta polypeptide saw uas txuas los ntawm tus choj disulfide. Ib qho activation peptide, C5a ua , uas yog ib qho anaphylatoxin uas muaj lub zog spasmogenic thiab chemotactic kev ua haujlwm, yog muab los ntawm alpha polypeptide ntawm cleavage nrog C5-convertase.
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