Video: Yam tshuaj tua kab mob twg yog novobiocin?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Novobiocin yog ib qho aminocoumarin tshuaj tua kab mob uas tau tsim los ntawm actinomycete Streptomyces niveus. Novobiocin khi rau DNA gyrase, thiab thaiv adenosine triphosphatase ( ATPase ) kev ua ub no. Lwm cov tshuaj tua kab mob hauv aminocoumarin chav kawm suav nrog coumermycin A1 thiab clorobiocin.
Kuj nug, dab tsi yog novobicin siv los kho?
Novobiocin, thiab lwm yam aminocoumarin tshuaj tua kab mob , inhibits kab mob DNA synthesis los ntawm lub hom phiaj ntawm cov kab mob DNA gyrase thiab cov enzyme DNA topoisomerase IV. Qhov no tshuaj tua kab mob tau siv los kho kab mob los ntawm cov kab mob gram-positive.
Ib tus kuj yuav nug, hom kab mob dab tsi uas novobiocin tua? Lub coumarin novobiocin yog tsim los ntawm Streptomyces (S. niveaus thiab S. spheroides), thiab nws lub hom phiaj tseem ceeb yog cov kab mob gram-positive. Nws ua los ntawm inhibiting cov kab mob gyrase ua haujlwm.
Tsis tas li ntawd, Novobiocin puas yog cov tshuaj tua kab mob dav dav?
Novobiocin yog ib qho aminocoumarin tshuaj tua kab mob cais tawm ntawm ntau hom Streptomyces. Novobiocin khoom pov thawj dav spectrum Kev ua haujlwm Gram +ve thiab tau siv hauv tsev kho mob. Novobiocin yog lub zog tiv thaiv kab mob DNA gyrase thiab ua raws li kev sib tw inhibitor ntawm ATPase cov tshuaj tiv thaiv catalysed los ntawm GyrB.
Puas yog novobiocin yog quinolone?
Ntxiv rau quinolones , ib txwm muaj cov kab mob DNA gyrase inhibitors, xws li coumarins, uas suav nrog novobiocin , kuj yog cov tshuaj tua kab mob (Maxwell, 1993; Kim and Ohemeng, 1998). Coumarins inhibit ATPase kev ua haujlwm ntawm DNA gyrase los ntawm kev sib tw nrog ATP rau kev khi rau GyrB subunit.
Pom zoo:
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