Cov molecules twg hauv insulin?
Cov molecules twg hauv insulin?

Video: Cov molecules twg hauv insulin?

Video: Cov molecules twg hauv insulin?
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Anonim

Cov mis molecular ntawm tib neeg insulin yog C257H383N65O77S6. Nws yog kev sib txuas ntawm ob peptide saw (dimer) npe hu ua A-saw thiab B-saw, uas txuas ua ke los ntawm ob daim ntawv cog lus disulfide. A-saw yog tsim los ntawm 21 cov amino acids , thaum B-chain muaj 30 residues.

Ntawm no, dab tsi molecule yog insulin tsim los ntawm?

Cov tshuaj insulin yog ib protein ntau tsim los ntawm ob txoj hlua, ib txoj hlua A (nrog 21 cov amino acids ) thiab B saw (nrog 30 cov amino acids ), uas txuas ua ke los ntawm sulfur atoms. Insulin yog muab los ntawm 74- cov amino acid prohormone molecule hu ua proinsulin.

Tsis tas li ntawd, hom twg ntawm cov molecules yog cov tshuaj insulin? Cov tshuaj insulin (suav nrog 2 α thiab 2 β subunits) muaj nyob ntawm qhov chaw ntawm lub hom phiaj hlwb xws li daim siab, nqaij thiab rog. Kev khi cov tshuaj insulin ua rau tyrosine autophosphorylation ntawm β subunit. Qhov no ces phosphorylates lwm substrates thiaj li hais tias ib tug signaling cascade yog pib thiab lom cov lus teb tshwm sim.

Raws li txoj cai, cov qauv tshuaj ntawm insulin yog dab tsi?

Cov tshuaj insulin yog tsim los ntawm ob peptide saw hu ua A saw thiab B saw. A thiab B txuas tau txuas ua ke los ntawm ob daim ntawv cog lus disulfide, thiab ib qho ntxiv disulfide tau tsim nyob hauv A saw. Hauv ntau hom tsiaj, A saw muaj 21 amino acids thiab B chain ntawm 30 amino acids.

Cov protein twg tsim cov tshuaj insulin?

INS gene muab cov lus qhia rau tsim tawm cov tshuaj hormones cov tshuaj insulin , uas yog qhov tsim nyog rau kev tswj hwm cov piam thaj hauv cov ntshav. Glucose yog cov suab thaj yooj yim thiab lub zog tseem ceeb rau ntau lub hlwb hauv lub cev.

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