Video: Dab tsi ua rankl?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
RANKL tau nthuav tawm hauv ntau cov ntaub so ntswg thiab cov kabmob xws li: cov leeg pob txha, thymus, daim siab, txoj hnyuv, txoj hnyuv me, qog adrenal, osteoblast, qog nqaij hlav qog nqaij hlav epithelial, prostate thiab pancreas.
RANKL.
| Muaj cov qauv | |
|---|---|
| PDB | showList ntawm PDB tus lej cim |
Ntawm no, qhov twg yog rankl tsim?
RANKL tshwm sim raws li homotrimeric protein thiab feem ntau yog daim nyias nyias ntawm cov osteoblastic thiab activated T hlwb los yog secreted los ntawm ib co hlwb, xws li activated T hlwb (43-45). Cov protein zais cia tau muab los ntawm daim nyias nyias ua los ntawm kev tiv thaiv kab mob proteolytic lossis lwm txoj kev sib txuas (46).
rankl sawv rau dab tsi? RANK yog tus receptor rau RANK-Ligand ( RANKL ) thiab ib feem ntawm RANK / RANKL /OPG taw qhia txoj hauv kev uas tswj hwm osteoclasst sib txawv thiab ua kom muaj zog. Nws yog cuam tshuam nrog kev txhim kho pob txha thiab kho, kev ua haujlwm ntawm lub cev tiv thaiv kab mob, kev txhim kho cov qog ntshav, kev tswj hwm cua sov, thiab kev txhim kho qog noj ntshav.
Yog li ntawd, osteoprotegerin tuaj qhov twg?
Osteoprotegerin ( OPG ) yog zais los ntawm osteoblasts thiab osteogenic stromal qia hlwb thiab tiv thaiv lub cev pob txha los ntawm cov pob txha ntau dhau los ntawm kev khi rau RANKL thiab tiv thaiv nws los ntawm kev cuam tshuam nrog RANK. RANKL/ OPG ratio nyob rau hauv cov pob txha pob txha yog yog li qhov tseem ceeb txiav txim siab ntawm pob txha loj hauv ib txwm muaj thiab kab mob xeev.
Puas yog rankl yog osteoblast?
RANKL yog qhia rau osteoblasts thiab T cells. Nws khi lub receptor RANK , uas yog tsim nyob rau hauv osteoclasts thiab lawv progenitors. Kev sib tham ntawm RANK nrog RANKL yog xav tau rau kev tsim osteoclast, sib txawv, ua kom muaj sia nyob thiab muaj sia nyob.
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