Video: Puas nco B hlwb ua rau somatic hypermutation?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Thaum tsis muaj AID, B hlwb tsis muaj peev xwm ua hla somatic hypermutation lossis tsim cov tshuaj tiv thaiv kab mob thib ob txawm hais tias lub hauv paus tsim kab mob 17 18. Peb pom tias AID yog qhov tseem ceeb rau kev hloov pauv hauv kev ua yeeb yam ntawm cov neeg tsis paub qab hau thiab cov tshuaj tiv thaiv kab mob xaiv nco B cell.
Tsuas yog li ntawd, dab tsi yog somatic hypermutation B hlwb?
Somatic hypermutation . Txhais. Somatic hypermutation yog txheej txheem uas tso cai B hlwb los hloov cov noob uas lawv siv los tsim cov tshuaj tiv thaiv. Qhov no ua rau B hlwb los tsim cov tshuaj tiv thaiv zoo uas tuaj yeem khi rau cov kab mob, kab mob thiab lwm yam kab mob.
Ib tug kuj yuav nug, qhov twg somatic hypermutation tshwm sim? Somatic hypermutation tshwm sim nyob rau hauv periphery nyob rau hauv germinal center follicles ntawm theem nrab lymphoid lub cev [93, 94] ib. Cov tshuaj tiv thaiv kab mob tsim los ntawm cov txheej txheem no tuaj yeem ua rau muaj kev cuam tshuam ntau ntxiv rau tus kheej-antigens.
Dhau li, ua li cas nco B cells tau qhib?
Nco B cell . Qhib los ntawm kev khi ntawm antigen rau qhov tshwj xeeb sib txuam receptor ntawm nws saum npoo, a B cell proliferate rau hauv ib tug clone. Ib co clonal hlwb sib txawv hauv plasma hlwb , uas yog luv-nyob hlwb uas zais cov tshuaj tiv thaiv tiv thaiv antigen.
Puas nco B hlwb yuav tsum tau qhib?
T-ywj siab nco B cell B1 hlwb yog B hlwb , uas ua tsis xav tau qee T ntawm tes pab hauv ua kom . Lawv tsim cov tshuaj tiv thaiv IgM innate. B1 nco hlwb tau khaws cia hauv peritoneum, ntawm no lawv tuaj yeem yog qhib tom qab rov ntsib dua ntawm antigen.
Pom zoo:
Lub ntsiab lus ntawm kev tsis nco qab tsis nco qab yog dab tsi?
Dissociative amnesia yog ib hom kev tsis sib haum xeeb uas cuam tshuam tsis muaj peev xwm rov qab tau cov ntaub ntawv tus kheej tseem ceeb uas yuav tsis feem ntau poob nrog qhov tsis nco qab. Feem ntau nws tshwm sim los ntawm kev raug mob los yog kev nyuaj siab. Kev kuaj mob yog raws keeb kwm tom qab txiav txim tawm lwm qhov ua rau amnesia
Ib feem ntawm lub paj hlwb puas cuam tshuam nrog kev nco?
amygdala Tom qab ntawd, ib tug kuj yuav nug, qhov chaw nco khaws cia rau hauv lub hlwb? Hippocampus. Lub hippocampus, nyob hauv hlwb temporal lobe, yog qhov twg episodic nco tau tsim thiab ntsuas rau kev nkag mus tom qab. Episodic nco yog autobiographical nco los ntawm cov xwm txheej tshwj xeeb hauv peb lub neej, zoo li kas fes peb tau nrog phooj ywg nyob rau lub lim tiam dhau los.
Dab tsi yog qhov sib txawv tseem ceeb ntawm kev tsis nco qab tsis nco qab thiab kev nco tsis nco qab?
Qhov sib txawv loj ntawm retrograde amnesia thiab anterograde amnesia yog cov hauv qab no: Retrograde amnesia yog qhov tsis muaj peev xwm rov qab nco tau yav dhau los thaum anterograde amnesia yog qhov tsis muaj peev xwm los tsim kev nco tshiab
Hom kev nco zoo li cas nrog rau lub sij hawm mus ncig ntawm lub hlwb?
Dab tsi yog cov yam ntxwv tseem ceeb ntawm kev xav mus sij hawm ntev? Nws yog Tulving [2] uas tau tsim lub sij hawm episodic nco kom paub meej tias peb lub peev xwm nco tau yav dhau los yog txheej txheem kev puas siab puas ntsws los ntawm lwm hom kev nco xws li lub cev nco (txoj kev nco) thiab paub qhov tseeb txog lub ntiaj teb (semantic nco)
Puas nco tau sab nraum lub hlwb?
Qhov kev nkag siab raug tshaj plaws nyob rau lub sijhawm tam sim no yog peb lub cim xeeb tsis tau khaws cia hauv lub hlwb lossis lub cev, tab sis hauv qee yam kev nco uas dhau ntawm lub cev nqaij daim tawv