Video: Dab tsi yog histone tails ua los ntawm?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Histone qab yog cov cheeb tsam hloov tau yooj yim uas flank ob kawg ntawm lub keeb kwm fold (Fig. 1(A)) [4, 5]. Hauv nucleosome, cov keeb kwm quav yog lub luag haujlwm rau kev tsim kom ruaj khov H2A, H2B thiab H3 – H4 dimers, thiab keeb kwm octamer yog tsim ntawm ob H2A -H2B dimers thiab ob H3 -H4 dimers.
Ib yam nkaus, tib neeg nug, keeb kwm keeb kwm yog dab tsi?
Histone /DNA kev sib cuam tshuam. Histones yog muaj los ntawm Feem ntau zoo them cov amino acid seem xws li lysine thiab arginine. Cov nqi zoo tso cai rau lawv los koom nrog cov DNA tsis zoo los ntawm kev sib cuam tshuam electrostatic.
Ib yam li ntawd, histones thiab lawv txoj haujlwm yog dab tsi? Hauv biology, histones yog alkaline heev cov protein pom nyob rau hauv eukaryotic ntawm tes nuclei uas pob thiab xaj DNA rau hauv cov qauv hu ua nucleosomes. Lawv yog tus thawj protein ntau Cheebtsam ntawm chromatin, ua haujlwm zoo ib yam puag ncig uas DNA cua, thiab ua lub luag haujlwm hauv cov noob kev cai.
Ib yam li ntawd, koj tuaj yeem nug, yuav ua li cas Histone cov protein khi rau DNA?
DNA raug them tsis zoo, vim yog pawg phosphate hauv nws cov phosphate-sugar backbone, yog li histones khi nrog DNA nruj heev. Cov no tau them tus nqi zoo cov protein uas ua raws li qhov tsis zoo-them DNA thiab tsim cov complexes hu ua nucleosomes.
Yuav hloov kho histones li cas?
A kev hloov kho histone yog covalent tom qab txhais lus kev hloov kho (PTM) rau keeb kwm cov protein uas suav nrog methylation, phosphorylation, acetylation, ubiquitylation, thiab sumoylation. Histone proteins ua rau pob DNA, uas qhwv ib ncig ntawm yim keeb kwm , nyob rau hauv chromosomes.
Pom zoo:
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