Video: Puas yog meropenem hepatotoxic?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Hepatotoxicity . Ntshav aminotransferase nce tau tshaj tawm hauv 1% txog 6% ntawm cov neeg tau txais kev txhaj tshuaj meropenem thaum muab rau txog 14 hnub. Cov kev nce qib no feem ntau yog hla, me me thiab asymptomatic; thiab tsis tshua muaj yuav tsum tau hloov koob tshuaj. Meropenem tseem tsis tau tshaj tawm tias ua rau daim siab tsis ua haujlwm.
Ntawm no, cov tshuaj twg yog hepatotoxic?
Cov hauv qab no tshuaj Feem ntau muaj feem xyuam nrog DILI: Chlorpromazine, amoxicillin-clavulanic acid, flucloxacillin, macrolides, tetracyclines, metoclopramide, chlorpheniramine, Betahistine, sulfasalazine, azathioprine, diclofenac, thiab antiepileptics Qhov siab tshaj plaws crude 3 cov neeg siv incid.
Puas yog meropenem npog E coli? Empiric kev pab them nqi yuav tsum suav nrog kev tiv thaiv E kev pab them nqi kho mob. Rau Ua coli mob plab hauv plab, tshuaj tua kab mob kuj yuav tsum suav nrog kev tiv thaiv anaerobic (piv txwv li, ampicillin thiab sulbactam lossis cefoxitin). Hauv kev kis mob hnyav, piperacillin thiab tazobactam, ua imipen thiab cilastatin, lossis meropenem tej zaum yuav siv tau.
Ib sab saum toj no, tus kab mob siab hepatotoxic yog dab tsi?
Hepatotoxicity (los ntawm hepatic toxicity) implies chemical-driven daim siab puas. Lwm yam tshuaj lom neeg tus neeg sawv cev , xws li cov uas siv hauv chaw kuaj mob thiab kev lag luam, tshuaj lom neeg (piv txwv li, microcystins) thiab tshuaj ntsuab tuaj yeem ua rau hepatotoxicity . Cov tshuaj uas ua rau lub siab raug mob hu ua hepatotoxins.
Puas yog ceftazidime hepatotoxic?
Ceftazidime yog semisynthetic, dav-spectrum, beta-lactam tshuaj tua kab mob rau kev tswj hwm niam txiv.
Pom zoo:
Puas yog kev khuv leej kev qaug zog yog kev puas siab puas ntsws?
Cov kws tshaj lij uas ua haujlwm hauv kev puas siab puas ntsws muaj kev pheej hmoo ntawm kev tsim kev puas siab puas ntsws rau lawv tus kheej. Lo lus "kev khuv leej neeg qaug zog" tau siv los piav txog qhov tsis zoo ntawm kev ua haujlwm hauv ib puag ncig kev puas siab puas ntsws rau tus neeg lub peev xwm kom muaj kev khuv leej rau lwm tus
Puas yog ntau tus cwj pwm tsis zoo yog kev puas siab puas ntsws?
Differential Diagnosis: Kev nyuaj siab loj heev
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Cov tshuaj tua kab mob twg yog hepatotoxic?
Ntau zaus thiab cov yam ntxwv ntawm cov tshuaj tiv thaiv kab mob hepatotoxicity Cov tshuaj tua kab mob tshwm sim amoxicillin / clavulanate 1-17 ib 100 000 daim ntawv tshuaj cephalosporins (ceftriaxone) txog 25% ntawm cov neeg laus thiab ∼ 40% ntawm cov neeg mob menyuam yaus Macrolides/ketolides per0004 prescriptions