Video: Yuav ua li cas T cell qhib?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Pab T hlwb ua qhib thaum lawv tau nthuav tawm nrog peptide antigens los ntawm MHC chav kawm II cov qauv, uas tau hais tawm ntawm qhov chaw ntawm antigen-nthuav tawm hlwb (APCs). Ib zaug qhib , lawv faib sai thiab zais cov cytokines uas tswj lossis pab tiv thaiv kev tiv thaiv kab mob.
Vim li ntawd, T cell activation txhais li cas?
T cell qhib yog txheej txheem kev tiv thaiv antigen ua rau kev nthuav dav thiab sib txawv ntawm cov neeg tsis paub qab hau T hlwb mus rau hauv effector hlwb . Teeb liab 2 tshwm sim thaum co qhib molecules nyob rau hauv T tes khi cov nqi protein rau ntawm APC lossis lub hom phiaj ntawm tes , qhov tseem ceeb tshaj plaws uas yog B7 protein.
Kuj Paub, dab tsi yog theem ob ntawm T cell qhib? Thawj kauj ruam hauv kev qhib txheej txheem yog TCR lees paub qhov tshwj xeeb txawv teb chaws epitope nthuav tawm hauv MHC II antigen-binding cleft. Cov kauj ruam thib ob cuam tshuam nrog kev sib cuam tshuam ntawm CD4 ntawm tus pabcuam T cell nrog thaj tsam ntawm MHC II cov qauv sib cais los ntawm antigen-binding cleft.
Ib yam nkaus, nws siv sijhawm ntev npaum li cas los qhib T cells?
Thaum koj muaj tus naive T tes , APC thiab cov tshuaj muaj feem cuam tshuam tam sim no (hauv vitro): Yog ntsuas ua kom los ntawm kev zais ntawm IFN-g, nws siv 24-48 teev kom pom cov lus teb ntsuas tau (los ntawm CBA, ELISA lossis ELISpot). Yog tias ntsuas CD107a qhia, koj yuav saib cov lus teb hauv 6 teev.
Yuav ua li cas lymphocytes tau qhib?
Kev ua kom lymphocyte tshwm sim thaum cov lymphocytes (B cells lossis T cells) tau tshwm sim los ntawm antigen-tshwj xeeb receptors ntawm lawv cov cell saum npoo. Qhov no ua rau cov cell loj tuaj thiab sib txawv rau hauv kev ua haujlwm tshwj xeeb cov lymphocytes.
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