Video: Vim li cas cov protein prion misfold?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Microscopic "qhov" yog tus yam ntxwv hauv prion -cuam tshuam cov ntaub so ntswg, ua rau cov nqaij tsim "spongy" architecture. Qhov no ua rau kev puas tsuaj ntawm cov ntaub so ntswg "spongy" hauv lub hlwb. Prions yog misfolded cov protein nrog lub peev xwm xa lawv misfolded hloov mus rau qhov sib txawv ntawm ib yam protein ntau.
Hauv qhov no, yuav ua li cas prions ua rau lwm cov protein kom yuam kev?
Cov kws tshawb fawb tau piav qhia nrog ib leeg-molecule qhov tseeb li cas tooj liab ions ua rau cov protein tsis zoo thiab seed misfolding thiab clumping ntawm nyob ze prion cov protein . Prion cov protein feem ntau pom nyob hauv lub hlwb. Qhov txawv txav ntawm prion cov protein ua rau lub hlwb puas tsuaj thiab cov tsos mob ntawm tus kab mob neurodegenerative.
Qhov thib ob, dab tsi ua rau prion? Prion kab mob yog ua los ntawm cov ntaub ntawv tsis raug ntawm prion protein, tseem hu ua PrP. Hauv txhua tus kab mob, tus prion protein (PrP) quav rau txoj kev tsis raug, dhau los ua prion , thiab ces ua lwm yam PrP molecules los ua ib yam. Prions tuaj yeem kis "ntsiag to" hla tus tib neeg lub hlwb tau ntau xyoo yam tsis muaj ua tej tsos mob.
Ib yam li ntawd, koj yuav nug, dab tsi ua rau cov protein ua kom yuam kev?
Protein misfolding yog ib qho xwm txheej ntawm tes uas tuaj yeem tshwm sim thoob plaws lub neej ntawm lub cell, ua los ntawm cov xwm txheej sib txawv suav nrog kev hloov pauv caj ces, kev txhais lus tsis raug, txawv txav protein ntau kev hloov kho, cua sov lossis oxidative kev nyuab siab, thiab kev ua tiav tsis tiav.
Koj yuav tua cov protein prion li cas?
Rau rhuav tshem a prion nws yuav tsum tau denatured rau lub ntsiab lus tias nws tsis tuaj yeem ua rau ib txwm muaj cov protein mus misfold. Kev tiv thaiv cua sov rau ob peb teev ntawm qhov kub siab heev (900 ° F thiab siab dua) yuav ntseeg tau rhuav tshem a prion.
Pom zoo:
Vim li cas cov kws tshawb fawb ntxig cov noob rau tib neeg cov insulin rau hauv cov kab mob?
Recombinant DNA yog cov kws tshawb fawb thev naus laus zis tsim los uas ua rau nws muaj peev xwm ntxig tib neeg cov noob mus rau hauv cov khoom siv ntawm cov kab mob sib kis. Qhov "recombinant" micro-organism tam sim no tuaj yeem tsim cov protein nkag los ntawm tib neeg cov noob. Cov kws tshawb fawb tsim tib neeg cov insulin insulin hauv chav kuaj
Cov kua qaub plab thiab cov zom zaub mov muaj txiaj ntsig zoo li cas rau cov qauv protein?
Lub plab acid tsis zom cov protein. Qhov tseeb, nws ua kom muaj enzyme hu ua pepsinogen uas tom qab ntawd dhau los ua pepsin uas zais los ntawm lub plab phab ntsa. Qhov enzyme no tsuas yog ua haujlwm nyob hauv thaj tsam pH ntawm 3.0 txog 5.0 thiab xav tau cov kua qaub los tswj hwm pH ntawd
Cov protein twg hauv qab no ua lub luag haujlwm tseem ceeb hauv kev khi cov tshuaj protein protein?
Albumin thiab al acid glycoprotein yog qhov tseem ceeb tshaj plaws thauj cov protein hauv cov ntshav. Albumin muaj cov chaw tshwj xeeb rau cov kua qaub thiab cov tshuaj yooj yim sib txuas thiab tuaj yeem cuam tshuam nrog lawv hauv cov ntshav vim tias qhov chaw thib peb raug daig tsuas yog digoxin
Vim li cas cov protein pom hauv cov ntshav plasma?
Ntshav proteins, tseem hu ua plasma proteins, yog cov proteins uas muaj nyob rau hauv cov ntshav plasma. Lawv ua haujlwm ntau yam sib txawv, suav nrog thauj lipids, cov tshuaj hormones, cov vitamins thiab cov zaub mov hauv kev ua haujlwm thiab ua haujlwm ntawm lub cev tiv thaiv kab mob. Tag nrho cov ntshav protein sib xyaw hauv lub siab tshwj tsis yog rau gamma globulins
Dab tsi yog cov protein protein ua lub luag haujlwm rau kev sib txuas ntawm cov tshuaj tiv thaiv?
Cov ntshav protein no tau tso rau hauv cov ntshav los ntawm cov cell uas lawv tau muab coj los ua ke. Feem ntau ntawm cov protein ntawm plasma yog tsim nyob rau hauv daim siab. Cov ntshav ntshav protein ntau yog cov ntshav albumin, qhov sib piv me me, lub luag haujlwm tseem ceeb ntawm uas yog khaws cov dej hauv cov ntshav los ntawm nws cov txiaj ntsig osmotic