![T cells ua li cas? T cells ua li cas?](https://i.answers-medical.com/preview/medical-health/13938407-how-do-t-cells-develop-j.webp)
Video: T cells ua li cas?
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2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Tiam ntawm T Cells
Lymphoid progenitors uas muaj tsim los ntawm hematopoietic qia hlwb hauv cov pob txha pob txha txav mus rau thymus kom ua tiav lawv cov antigen-ywj siab kom loj hlob rau hauv kev ua haujlwm T hlwb . Hauv thymus, T hlwb tsim lawv qhov tshwj xeeb T cov cim ntawm tes, suav nrog TCR, CD3, CD4 lossis CD8, thiab CD2.
Hauv qhov no, T hlwb ua haujlwm li cas?
Pab T cells dhau los ua haujlwm thaum lawv tau nthuav tawm nrog peptide antigens los ntawm MHC chav kawm II cov qauv, uas tau hais tawm ntawm qhov chaw ntawm antigen-nthuav tawm hlwb (APCs). Ib zaug qhib , lawv faib sai thiab zais cov cytokines uas tswj lossis pab tiv thaiv kev tiv thaiv kab mob.
Tsis tas li ntawd, dab tsi ua rau cytotoxic T? Cytotoxic T cells yog qhib los ntawm dendritic hlwb uas qhia txog antigen-loaded class I molecules. Dendritic hlwb noj intact hlwb (cross-priming) los yog dawb antigens. Lub teeb liab thib ob yog muab los ntawm CD28 rau T hlwb cuam tshuam nrog B7-1 ntawm antigen-presenting hlwb.
Ua ke, qhov twg yog T cells tsim rau cov neeg laus?
Hauv cov neeg laus, kev loj hlob tshiab T hlwb hauv cov thymus qeeb thiab T -cov lej raug khaws tseg los ntawm kev faib kev paub tab T hlwb sab nraum lub hauv nruab nrab lymphoid nruab nrog cev. Tshiab B. hlwb ntawm qhov tod tes, yog tas li tsim tawm los ntawm cov pob txha pob txha, txawm nyob rau hauv cov laus.
Lub luag haujlwm ntawm T cell yog dab tsi?
Cov ntsiab lus tseem ceeb: T Cells T cell yog cov lymphocyte tiv thaiv kab mob hlwb uas tiv thaiv lub cev los ntawm cov kab mob thiab mob qog noj ntshav hlwb . T hlwb pib los ntawm cov pob txha pob txha thiab paub tab nyob rau hauv lub thymus. Lawv yog ib qho tseem ceeb rau ntawm tes mediated immunity thiab ua kom lub cev tiv thaiv kab mob hlwb los tua tus kab mob.
Pom zoo:
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Kev txhais lus kho mob ntawm B cell B cell: Ib hom qe ntshav dawb thiab, tshwj xeeb, yog hom lymphocyte. Ntau lub B hlwb paub tab hu ua ntshav plasma uas tsim cov tshuaj tiv thaiv kab mob (cov protein) tsim nyog los tawm tsam kev kis mob thaum lwm cov cell B loj hlob rau hauv kev nco B hlwb
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Kev kuaj zis tuaj yeem qhia tau tias koj muaj "tsawg", "nruab nrab," lossis "ntau" cov hlwb epithelial hauv koj cov zis. Nws yog ib txwm muaj ib txog tsib squamous epithelial cells ib lub zog muaj zog teb (HPF) hauv koj cov zis. Muaj tus lej tsawg lossis ntau lub cell yuav qhia tau tias: kab mob los yog kab mob tso zis (UTI) mob raum lossis mob siab
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Tom qab ntawd koj lub cev tuaj yeem tsim cov riam phom zoo tshaj plaws tiv thaiv cov neeg tawm tsam, uas tuaj yeem yog kab mob, kab mob lossis kab mob parasites. Lwm hom T-cells paub thiab tua cov kab mob uas muaj kab mob ncaj qha. Qee qhov pab B-cells ua cov tshuaj tiv thaiv kab mob, uas nthuav dav thiab khi rau antigens. T-cell (txiv kab ntxwv) tua kab mob qog noj ntshav (mauve)
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T hlwb yog li ntawd hu ua vim lawv feem ntau tsim nyob rau hauv lub thymus. Raws li cov npe hais tias pab T hlwb 'pab' lwm lub hlwb ntawm lub cev tiv thaiv kab mob, thaum cytotoxic T hlwb tua cov kab mob kis kab mob thiab qog. Tsis zoo li cov tshuaj tiv thaiv kab mob, TCR tsis tuaj yeem khi cov tshuaj tiv thaiv ncaj qha
Lub luag haujlwm ntawm T cells thiab B cells yog dab tsi?
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T cells koom nrog hauv kev tiv thaiv kab mob ntawm tes, qhov B hlwb feem ntau yog lub luag haujlwm rau kev tiv thaiv kev dag ntxias (hais txog cov tshuaj tiv thaiv). Kev ua haujlwm ntawm T hlwb thiab B hlwb yog kom paub txog cov 'tsis yog tus kheej' antigens, thaum lub sijhawm ua haujlwm hu ua antigen nthuav qhia