Video: Lub luag haujlwm ntawm perforin yog dab tsi?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Muaj nuj nqi . Perforin yog lub pore tsim cytolytic protein pom nyob rau hauv granules ntawm cytotoxic T lymphocytes (CTLs) thiab natural killer cells (NK cells). Thaum degranulation, perforin khi rau lub hom phiaj ntawm tes cov ntshav ntshav, thiab cov oligomerises nyob rau hauv Ca2+ yam ua kom tsim cov pores ntawm lub hom phiaj ntawm tes.
Ntxiv thiab, perforin thiab Granzymes yog dab tsi?
Perforin thiab Granzyme Perforin yog pore-forming protein thiab tseem hu ua cytoplasmic granule toxins. Granzyme yog tsev neeg ntawm cov txheej txheem muaj feem cuam tshuam txog serine proteases khaws cia hauv cytotoxic granules ntawm cytotoxic lymphocytes (CLs).
Tsis tas li ntawd, puas yog perforin ib cytokine? NK cells muaj npe nrov rau lawv lub peev xwm los tua cov kab mob sib kis lossis hloov pauv cov tswv tsev los ntawm kev tso cytotoxic granules uas muaj granzymes thiab perforin . Peb qhia tias cytokines IFN-gamma thiab TNF raug muag thiab zais ntawm txoj kev sib txawv dua li perforin.
Tom qab ntawd, ib tus tseem tuaj yeem nug, ua li cas perforin ua rau tuag ntawm cov kab mob sib kis?
Human T kev cai hlwb tuaj yeem siv perforin txoj kev mus ua lub hom phiaj autologous cell tuag . Cytotoxic T lymphocytes thiab tua neeg ntuj hlwb siv cov perforin /granzyme txoj hauv kev tua tus kab mob mob hlwb thiab qog hlwb . Kev hloov pauv hauv cov noob tseem ceeb rau txoj hauv kev no yog txuam nrog ntau tus tib neeg kab mob.
Lub xovtooj twg tso tawm Granzymes thiab perforin?
Granzymes yog serine proteases tso tawm los ntawm cytoplasmic granules hauv cytotoxic T hlwb thiab neeg tua neeg ntuj (NK) hlwb . Lawv induce programmed ntawm tes tuag (apoptosis) hauv lub hom phiaj ntawm tes , yog li tshem tawm hlwb uas tau ua mob qog noj ntshav lossis kis tus kab mob lossis kab mob.
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