Leej twg pom kab mob diphtheria?
Leej twg pom kab mob diphtheria?

Video: Leej twg pom kab mob diphtheria?

Video: Leej twg pom kab mob diphtheria?
Video: Mim Oom Lais Kis Kab Mob Covid -19 3/19/22 2024, Lub Xya hli ntuj
Anonim

Diphtheria toxin yog nrhiav tau xyoo 1888 los ntawm ilemile Roux thiab Alexandre Yersin. Xyoo 1890, Emil Adolf von Behring tau tsim cov tshuaj tiv thaiv tshuaj lom raws li cov ntshav ntawm nees txhaj tshuaj tiv thaiv kab mob attenuated.

Tsis tas li cov lus nug yog, kab mob diphtheria toxin tuaj qhov twg los?

Diphtheria toxin yog secreted los ntawm Corynebacterium diphtheriae raws li ib tug tib polypeptide saw muaj ob lub ntsiab tseem ceeb: DT-A, uas yog nqa lub active site rau ADP ribosylation ntawm EF-2, thiab DT-B, uas txhawb kev khi ntawm tshuaj lom rau cov hlwb thiab nkag mus ntawm A saw rau hauv cytosolic compartment.

Ib yam nkaus, kab mob diphtheria toxin ua dab tsi? Diphtheria toxin (DT) yog ib qho protein ntau ntxiv ntawm Corynebacterium diphtheriae uas txwv tsis pub cov protein sib sau thiab tua cov kab mob uas raug mob.

Kuj paub yog, leej twg nrhiav pom kab mob npaws?

Cov kab mob hawb pob bacillus yog nrhiav tau thiab txheeb xyuas los ntawm German bacteriologists Edwin Klebs thiab Friedrich Löffler.

Yuav ua li cas diphtheria toxin tua cov hlwb?

Diphtheria toxin tua cov hlwb los ntawm inhibiting eukaryotic protein synthesis, thiab nws cov txheej txheem ntawm kev ua tau nthuav dav. Cov haujlwm ADP-ribosylation ntawm diphtheria toxin yog txiav txim siab tag nrho los ntawm A fragment, thiab tsis muaj feem ntawm B fragment yog xav tau rau kev ua haujlwm catalytic.

Pom zoo: