Video: Dab tsi yog qhov kev xaiv zoo hauv thymus?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Hauv thymus ua Lawv tau dhau los ua cov txheej txheem ntawm kev loj hlob, uas suav nrog kev ua kom lub hlwb ua haujlwm tawm tsam antigens (" kev xaiv zoo "), tab sis hais tias lawv tsis hnov mob tawm tsam antigens pom ntawm lub cev nqaij daim tawv ("tsis zoo xaiv "). Txhua T cell muaj qhov txawv ntawm T cell receptor, haum rau ib yam khoom tshwj xeeb, hu ua antigen.
Ib yam li ntawd, nws tau nug, qhov kev xaiv zoo ntawm T cells yog dab tsi?
Kev xaiv zoo tshwm sim thaum ob zoo T cell khi cortical epithelial hlwb nthuav qhia Chav Kawm I lossis Chav Kawm II MHC ntxiv rau tus kheej peptides uas muaj kev sib raug zoo txaus kom tau txais cov teeb liab ciaj sia taus.
Ib yam li ntawd, thymic xaiv yog dab tsi? Thymic xaiv yuav siv qhov chaw hauv thymus ua thiab kwv yees li 2% ntawm qhov qub, T hlwb tsis paub tab muaj txoj sia nyob ntawm txoj kev no. Qhov tshwm sim los ntawm qhov no xaiv yog cov pejxeem ntawm T-cell clones, txhua tus muaj peev xwm lees paub, raws li complexed nrog MHC, ntau txawv teb chaws, piv txwv li, exogenous antigens, tab sis tsis yog nws tus kheej antigens.
Tseem paub, qhov kev xaiv zoo thiab tsis zoo yog dab tsi?
Hauv biology. Kev xaiv tsis zoo (ntuj xaiv ), xaiv tshem tawm ntawm alleles tsawg uas ua rau muaj kev phom sij. Kev xaiv tsis zoo (artificial xaiv ), thaum tsis zoo es tsis yog zoo , yam ntxwv ntawm hom tsiaj raug xaiv rau.
Dab tsi yog qhov zoo thiab tsis zoo xaiv ntawm T lymphocytes?
Tom ntej no, kev xaiv zoo kuaj tias T hlwb tau ua tiav kev hloov pauv lawv qhov chaw TCRα thiab muaj peev xwm lees paub peptide-MHC cov teeb meem nrog kev sib raug zoo uas tsim nyog. Kev xaiv tsis zoo nyob rau hauv medulla ces obliterates T hlwb uas khi heev rau nws tus kheej-antigens qhia ntawm MHC molecules.
Pom zoo:
Dab tsi yog qhov kev nkag siab tsis tu ncua thiab dab tsi yog qhov loj me me qhov ntev xim tsis tu ncua zoo li qub)?
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