Video: Puas yog endostatin FDA pom zoo?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Endostatin ua yog pom zoo los ntawm US Food and Drug Administration ( FDA ) rau kev kho mob ntawm NV-txog mob qog noj ntshav; Yog li, nws yuav yog ib qho tshuaj ntxiv uas tuaj yeem muab ntxiv rau kev kho mob los tiv thaiv VEGF los kho cov pob txha NV- thiab lymphangiogenesis ntsig txog mob.
Kuj paub, endostatin ua haujlwm li cas rau mob qog noj ntshav?
Tsev kawm ntawv ntawm Wisconsin Comprehensive Cancer Center yog ib ntawm ob qhov chaw los ua kev sim tib neeg ntawm endostatin , muaj peev xwm cog lus mob qog noj ntshav kev kho mob uas zoo li ua hauj lwm ib feem los ntawm kev cuam tshuam kev loj hlob ntawm cov hlab ntsha uas txhawb nqa qog hlwb.
Tsis tas li, tau tshawb pom endostatin li cas? Endostatin yog ib qho kev tiv thaiv endogenous ntawm angiogenesis. Nws tau pom thawj zaug zais hauv kev tshaj xov xwm ntawm cov tsis-metastasizing nas hlwb los ntawm hemangioendothelioma cell kab hauv 1997 thiab tom qab ntawd tau pom hauv tib neeg. Pro-angiogenic thiab anti-angiogenic yam tseem tuaj yeem tsim los ntawm proteolysis thaum coagulation cascades.
Ntxiv mus, yam tshuaj twg yog angiostatin thiab endostatin?
Angiostatin thiab endostatin Nws tau pom tias yog ib feem sab hauv ntawm plasminogen. Cov kab no muaj cov qauv kringle, uas ua raws li lawv cov qauv disulfide, tau pom tias inhibit angiogenesis. Angiostatin tshuaj muaj plaub ntawm tsib plasminogen kringle qauv.
Vim li cas cov qog nqaij hlav cancer yuav tsum dhau los ua angiogenic?
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