Dab tsi ntawm tus inhibitor yog aspirin?
Dab tsi ntawm tus inhibitor yog aspirin?

Video: Dab tsi ntawm tus inhibitor yog aspirin?

Video: Dab tsi ntawm tus inhibitor yog aspirin?
Video: Khawv koob thim dab xuas ntawv txaug thim tus ua ntsuab tsu yaj 12 Dec 2018 2024, Lub Xya hli ntuj
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Aspirin ua raws li tus neeg sawv cev acetylating qhov twg pawg acetyl tau txuas nrog covalently txuas rau cov serine seem hauv qhov chaw nquag ntawm COX enzyme. Qhov no ua rau cov tshuaj aspirin sib txawv los ntawm lwm cov NSAIDs (xws li diclofenac thiab ibuprofen), uas yog cov thim rov qab tuaj yeem txwv tsis pub siv.

Tsis tas li ntawd, cov tshuaj aspirin puas yog prostaglandin inhibitor?

Lub mechanism ntawm kev ua ntawm tshuaj aspirin . Nws ua pov thawj tias tshuaj aspirin thiab lwm yam tshuaj uas tsis yog-steroid anti-inflammatory (NSAIDs) inhibit kev ua haujlwm ntawm cov enzyme tam sim no hu ua cyclooxygenase (COX) uas ua rau tsim cov prostaglandins (PGs) uas ua rau mob, o, mob thiab kub taub hau.

Ib yam li ntawd, cov tshuaj aspirin khi rau dab tsi? Cov txiaj ntsig no qhia tias cov tshuaj aspirin yog ib qho allosteric inhibitor ntawm B2 receptor, ib qho cuab yeej uas yuav koom nrog hauv nws txoj kev kho mob. kev ua.

Ib sab ntawm qhov no, tshuaj aspirin ua haujlwm li cas tiv thaiv kab mob?

Antithrombotic kev ua ntawm tshuaj aspirin ( acetylsalicylic acid ) yog vim kev txwv tsis pub ua haujlwm ntawm platelet los ntawm acetylation ntawm platelet cyclooxygenase (COX) ntawm qhov ua haujlwm tseem ceeb amino acid serine529. Txawm li cas los xij, muaj txiaj ntsig zoo tshuaj tiv thaiv kab mob koob tshuaj tshuaj aspirin yog txuam nrog kev pheej hmoo los ntshav.

Cov tshuaj aspirin thaiv kev mob li cas?

Tshuaj aspirin ua haujlwm los ntawm kev thaiv kev tsim cov prostaglandins, kev hloov pauv hauv cov hlwb uas tswj qhov mob thiab mob , ntawm lwm yam. Yog vim li cas tshuaj aspirin nres mob me mob thiab mob. Tab sis qhov ntawd yog txoj koob hmoov thiab foom tsis zoo. Lawv hu ua nonsteroidal anti- mob cov tshuaj, lossis NSAIDs.

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