Video: Dab tsi yog interleukin activates macrophages?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Cov npe ntawm tib neeg interleukins
| Lub npe | Qhov chaw | Muaj nuj nqi |
|---|---|---|
| IL-1 | macrophages , B hlwb, monocytes, dendritic hlwb | co-stimulation |
| maturation & loj hlob | ||
| ua kom | ||
| o, me me induce mob theem tshwm sim, loj npaum li cas induce kub taub hau |
Kuj paub yog, yuav ua li cas macrophages tau qhib?
Activated macrophage . Macrophages tuaj yeem yog qhib los ntawm cytokines xws li interferon-gamma (IFN-gamma) thiab cov kab mob endotoxins, xws li lipopolysaccharide (LPS). Activated macrophages hla ntau qhov kev hloov pauv uas tso cai rau lawv tua cov kab mob kis lossis cov kab mob sib kis.
Kuj Paub, Dab tsi Cytokines raug tso tawm los ntawm macrophages? Thaum macrophages raug rau inflammatory stimuli, lawv secrete cytokines xws li qog necrosis factor ( TNF ), IL-1 , IL-6, IL-8, thiab IB-12 . Txawm hais tias monocytes thiab macrophages yog qhov tseem ceeb ntawm cov cytokines, lawv kuj tau tsim los ntawm cov lymphocytes, endothelial hlwb, thiab fibroblasts.
Ib yam li ntawd, tib neeg nug, dab tsi hlwb ua macrophages qhib?
Macrophages tshwj xeeb hlwb koom nrog hauv kev tshawb nrhiav, phagocytosis thiab kev puas tsuaj ntawm cov kab mob thiab lwm yam kab mob phem. Ib qho ntxiv, lawv tseem tuaj yeem nthuav qhia antigens rau T. hlwb thiab pib mob los ntawm kev tso cov molecules (hu ua cytokines) uas qhib lwm yam hlwb.
Lub luag haujlwm ntawm interleukins yog dab tsi?
Interleukin (IL), ib qho ntawm ib pawg ntawm cov proteins uas tshwm sim los ntawm kev sib txuas lus ntawm cov hlwb. Interleukins tswj kev loj hlob ntawm tes, sib txawv, thiab motility. Lawv yog ib qho tseem ceeb tshwj xeeb hauv stimulating lub cev tiv thaiv kab mob, xws li o.
Pom zoo:
Dab tsi yog glycoprotein dab tsi yog ib qho ntawm kev siv glycoproteins?
Glycoproteins yog cov protein uas muaj cov oligosaccharide saw (glycans) covalently txuas nrog cov amino acid sab-saw. Glycoproteins kuj tseem yog ib qho tseem ceeb ua ke ntawm cov protein, uas lawv ua lub luag haujlwm hauv kev sib cuam tshuam ntawm tes -cell
Lub luag haujlwm ntawm interleukin 1 yog dab tsi?
Interleukin-1: Cov protein tsim los ntawm ntau lub cell, suav nrog macrophages, interleukin-1 nce lub cev kub, txhawb kev tsim cov interferon, thiab txhawb kev loj hlob ntawm cov kab mob sib ntaus sib tua hlwb, ntawm lwm cov haujlwm
Yuav ua li cas macrophages ntes cov kab mob?
Macrophage yog lub loj, phagocytic cell uas nkag mus rau cov khoom txawv teb chaws thiab kab mob. Macrophages lees paub PAMPs ntawm kev ua tiav cov qauv lees paub (PRRs). PRRs yog cov molecules ntawm macrophages thiab dendritic hlwb uas nyob rau hauv kev sib cuag nrog ib puag ncig sab nraud thiab tuaj yeem paub txog PAMPs thaum tam sim no
Thawj qhov kev txiav txim ntawm Oprelvekin neumega uas yog tshuaj nyob rau hauv kev faib tawm interleukin IL yog dab tsi?
Tshem tawm ib nrab-lub neej: 6.9 ± 1.7h
Lub luag haujlwm tseem ceeb ntawm macrophages hauv cov ntaub so ntswg yog dab tsi?
Macrophages pab tshem tawm invaders los ntawm engulfing txawv teb chaws cov ntaub ntawv thiab pib lub cev tiv thaiv kab mob. Cov hlwb no tuaj yeem kho nyob rau hauv ib qho chaw, xws li cov qog ntshav, lossis lawv tuaj yeem mus ncig hauv qhov chaw sib txuas ntawm cov nqaij mos. Hom cell feem ntau nyob rau hauv cov ntaub so ntswg lymphoid yog lymphocyte