Video: Dab tsi yog tus qauv ntaus ntau yam mob qog noj ntshav?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Knudson hypothesis, tseem hu ua ob- ntaus hypothesis, yog qhov hypothesis uas feem ntau qog suppressor noob xav kom ob leeg alleles tsis ua haujlwm, los ntawm kev hloov pauv lossis los ntawm epigenetic ntsiag to, ua rau muaj kev hloov pauv phenotypic. Nws tau xub tsim los ntawm Alfred G.
Nyob rau hauv no txoj kev, dab tsi yog ntaus los ntawm ntau yam hit qauv ntawm mob cancer?
ntaus ntau hypothesis txhais. Lub tswv yim hais tias ib lub xov tooj ntawm tes yuav tsum tau txais cov xwm txheej ntawm kev hloov pauv kom ua rau mob qog noj ntshav lossis mob qog noj ntshav.
Tsis tas li ntawd, qhov kwv yees qhov nruab nrab ntawm cov kev hloov pauv uas yuav tsum tau ua rau mob qog noj ntshav yog dab tsi? Cov kws tshawb fawb los ntawm Wellcome Trust Sanger Institute thiab lawv cov koom tes tau hloov kho cov txheej txheem los ntawm thaj chaw ntawm kev hloov pauv kom paub tseeb tias, ntawm nruab nrab ,, 1-10 ib kev hloov pauv yog xav tau rau mob qog noj ntshav kom sawv.
Tsis tas li ntawd, ntau txoj kev xav yog dab tsi?
Knudson hypothesis, tseem hu ua ob- ntaus hypothesis, yog qhov kev xav tias feem ntau cov noob xav tau ob qho kev hloov pauv los ua kom muaj kev hloov pauv phenotypic. Nws tau tsim thawj zaug los ntawm Alfred G. Knudson hauv xyoo 1971 thiab coj ncaj qha rau kev txheeb xyuas cov noob caj noob ces ntsig txog kev mob qog noj ntshav.
Leej twg tsim txoj kev tshawb nrhiav caj ces rau kev tsim mob qog noj ntshav hauv xyoo 1989?
Zoo li ntau qhov kev xav tseem ceeb hauv kev tshawb fawb, Knudson's "two-hit" hypothesis tau ntsib nrog kev tsis ntseeg thaum nws tau luam tawm thawj zaug hauv xyoo 1971, tab sis Knudson qhov kev nkag siab zoo rau hauv txoj kev loj hlob ntawm mob qog noj ntshav tuav qhov cuam tshuam rau ob qho tib si mob qog noj ntshav kev kho mob thiab kev tiv thaiv.
Pom zoo:
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