Video: Puas yog Alpha 2 ua rau vasoconstriction?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Lub luag hauj lwm ntawm cov alpha ( 2 ) -AR tsev neeg tau paub ntev los suav nrog presynaptic inhibition ntawm kev tso tawm cov tshuaj xa mus rau lub cev, txo qis kev nkag siab zoo ntawm cov tsheb khiav mus los, vasodilation thiab vasoconstriction . Cov lus teb nyuaj no yog mediated los ntawm ib qho ntawm peb hom subtypes uas txhua tus tshwj xeeb cuam tshuam rau ntshav siab thiab ntshav khiav.
Ua kom pom qhov no, ua li cas alpha 2 receptors ua rau vasoconstriction?
Ua kom muaj kev nkag siab zoo rau sab hauv cov hlab ntshav ua rau cov leeg sib zog ua haujlwm ( vasoconstriction ) txo qis caliber ntawm cov hlab ntsha lossis leeg. Alpha - 2 cov tshuaj adrenoceptors yog tam sim no ntawm presynaptic cov hlab ntsha dav dav thiab, thaum qhib, txwv tsis pub tso tawm norepinephrine.
Ib tus kuj yuav nug, alpha 2 agonists ua dab tsi? α 2 agonist : txwv tsis pub ua haujlwm adenylyl cyclase, txo cov hlab ntsha vasomotor nruab nrab-nruab nrab CNS ua kom; siv raws li antihypertensive, sedative & kev kho mob ntawm kev quav yeeb quav tshuaj thiab cov tsos mob tshem tawm cawv).
Kuj Paub, ua li cas alpha 2 agonists cuam tshuam rau ntshav siab?
Alpha 2 receptors nyob rau hauv lub paj hlwb thiab nyob ib puag ncig cuam tshuam kev ua siab zoo thiab yog li qis ntshav siab . Alpha 2 tus txais agonists xws li clonidine los yog guanabenz txo qhov nruab nrab thiab peripheral sympathetic overflow thiab ntawm peripheral presynaptic receptors yuav txo tau peripheral neurotransmitter tso tawm.
Alpha 1 thiab alpha 2 receptors ua dab tsi?
Alpha 1 receptors yog cov classic postsynaptic alpha receptors thiab muaj nyob rau ntawm vascular du nqaij. Lawv txiav txim siab ob qho kev tiv thaiv arteriolar thiab cov leeg ntshav, thiab yog li BP. Alpha 2 receptors tau pom ob leeg hauv lub hlwb thiab nyob ib puag ncig. Hauv lub paj hlwb, lawv hloov pauv kev nkag siab zoo.
Pom zoo:
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