Video: Qhov sib txawv ntawm Phase 1 thiab Phase 2 metabolism yog dab tsi?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Theem Cov tshuaj tiv thaiv II yog cov tshuaj tiv thaiv kev sib txuas uas ib txwm muaj nyob rau niaj hnub no hauv lub cev yog ntxiv rau qhov chaw reactive ntawm lub Theem I metabolite. Qhov tshwm sim yog cov khoom sib xyaw ua ke uas muaj dej ntau dua li cov xenobiotic thawj los yog Theem I metabolite.
Yooj yim li ntawd, dab tsi yog 2 theem ntawm cov metabolism hauv?
Metabolism feem ntau muab faib ua ob theem : Theem 1 metabolism Muaj cov tshuaj tiv thaiv xws li oxidation (feem ntau), txo qis thiab hydrolysis. Muaj peb qhov ua tau los ntawm theem 1 metabolism . Cov tshuaj ua tsis muaj zog kiag li.
Tseem Paub, Phase 1 thiab 2 cov metabolism tshwm sim qhov twg? Cov enzymes koom nrog hauv Theem I cov tshuaj tiv thaiv feem ntau yog nyob hauv qhov kawg ntawm qhov reticulum ntawm daim siab cell, lawv hu ua microsomal enzymes. Theem II metabolism cuam tshuam nrog kev qhia ntawm hom tsiaj hydrophilic endogenous, xws li glucuronic acid lossis sulfate, rau cov tshuaj molecule.
Ntxiv rau qhov no, Phase 2 tshuaj metabolism yog dab tsi?
Theem Kuv tshua ntawm tshuaj metabolism koom nrog oxidation, txo qis, lossis hydrolysis ntawm niam txiv tshuaj , ua rau nws hloov pauv mus rau ntau qhov chaw muaj lub ncov qaumteb qabteb. Phase II cov tshuaj tiv thaiv muaj kev sib txuas los ntawm kev sib txuas tshuaj lossis nws cov metabolites mus rau lwm cov qauv, xws li glucuronidation, acylation, sulfate, lossis glicine.
Vim li cas cov tshuaj sib txuas hauv Phase 2 metabolism?
Kev sib txuas . Glucuronidation, feem ntau theem II cov tshuaj tiv thaiv, tsuas yog ib qho uas tshwm sim hauv lub siab microsomal enzyme system. Glucuronides yog zais hauv cov kua tsib thiab tshem tawm hauv cov zis. Yog li, kev sib txuas ua ntau tshuaj ntau dua thiab yooj yim tso tawm los ntawm ob lub raum.
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