Video: Cov kab mob dab tsi yog txuas nrog kev hloov pauv ntawm cov qog nqaij hlav qog ntshav?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Kev hloov pauv qub txeeg qub teg ntawm ob lwm qog suppressor noob , BRCA1 thiab BRCA2, yog lub luag haujlwm rau caj ces mob qog noj ntshav mis, uas suav txog 5 txog 10% ntawm tag nrho cov mob qog noj ntshav lub mis.
Tom qab ntawd, puas hloov pauv cov qog nqaij hlav qog thiab oncogenes nqa ntau hom kev hloov pauv?
Dominant nce-of-function kev hloov pauv nyob rau hauv protooncogenes thiab recessive poob-of-function kev hloov pauv nyob rau hauv qog - noob noob suppressor yog oncogenic ua . Ib qho qhib kev hloov pauv ntawm ib qho ntawm ob qho alleles ntawm proto- oncogene hloov nws mus rau ib qho oncogene , uas ua tau induce transformation nyob rau hauv cultured cell los yog mob qog noj ntshav hauv tsiaj.
Tseem Paub, yuav muaj dab tsi tshwm sim yog tias muaj kev hloov pauv hauv p53 noob? Feem ntau TP53 kev hloov pauv hloov tib cov amino acids hauv p53 ua , uas ua rau zus tau tej cov altered version ntawm lub protein ntau uas tsis tuaj yeem tswj kev loj hlob ntawm tes thiab tsis tuaj yeem ua rau apoptosis hauv hlwb nrog hloov pauv los yog puas DNA. Raws li qhov tshwm sim, DNA puas tuaj yeem sib sau hauv cov hlwb.
Kuj paub, vim li cas kev hloov pauv hauv cov qog nqaij hlav suppressor noob rov ua haujlwm?
Tumor suppressor noob yog rov ua dua ntawm qib cellular thiab yog li tsis muaj kev cuam tshuam ntawm ob qho tib si alleles xav tau. Qhov no feem ntau ua tiav los ntawm kev hloov pauv ntawm ib qho allele thiab tshem tawm ntawm qhov thib ob allele. Thaum kawg qee qhov kev hloov pauv ua raws li qhov tseem ceeb tsis zoo, thiab ua tau zoo ib qho xwm txheej tsis ua haujlwm rau ob qho tib si alleles.
Puas yog p53 kev hloov pauv tseem ceeb lossis rov ua dua?
Muaj kev zam rau txoj cai ob-ntaus rau cov qog nqaij hlav, xws li qee yam kev hloov pauv hauv p53 ua cov khoom lag luam. p53 vim tuaj yeem ua haujlwm raws li a tseem ceeb negative, meaning tias a npe p53 protein tuaj yeem tiv thaiv kev ua haujlwm ntawm cov protein uas tsim los ntawm cov khoom tsis- hloov pauv allele.
Pom zoo:
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