Puas yog diacylglycerol yog tus xa xov thib ob?
Puas yog diacylglycerol yog tus xa xov thib ob?

Video: Puas yog diacylglycerol yog tus xa xov thib ob?

Video: Puas yog diacylglycerol yog tus xa xov thib ob?
Video: Nkauj niam tais tuag vauv tawm tshiab (3/16/2021) 2024, Lub Xya hli ntuj
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Diacylglycerol (DAG) yog qhov muaj txiaj ntsig tus tub txib thib ob uas activates proteins koom tes nyob rau hauv ib tug ntau yam ntawm signaling cascades. Txij li thaum lawv tuaj yeem cuam tshuam rau DAG thiab phosphatidic acid (PA) cov cim, DGK kev ua si ua lub luag haujlwm tseem ceeb hauv ntau txoj hauv kev lipid signaling.

Ib sab ntawm no, puas yog CAMP tus xa xov thib ob?

Cylic AMP ( CAMP ) yog dej-soluble tus tub txib thib ob pom hauv eukaryotic thiab prokaryotic cells. Cov tshuaj intracellular ntau ntawm cyclic AMP yog kwv yees li 0.1-1.0 ΜM, nce 20-npaug hauv vib nas this ntawm kev ua haujlwm.

Qhov thib ob, qhov txawv ntawm thawj tus tub txib thiab tus tub txib thib ob yog dab tsi? Thawj tus tub txib yog ligand, tus tub txib thib ob yog ib qho me me, tsis muaj protein ntau ntawm ib lub teeb liab transduction txoj kev. cAMP qhib cov protein kinase A, uas ua rau cov cell teb.

Los ntawm qhov ntawd, tus xa xov thib ob yog dab tsi thiab ob yam ntxwv ntawm tus xa xov thib ob yog dab tsi?

Ob tug tub txib poob rau hauv plaub chav kawm tseem ceeb: cyclic nucleotides, xws li cAMP thiab lwm cov tshuaj sib tov uas qhia tau nyob hauv cytosol; lipid cov tub txib uas teeb liab nyob rau hauv daim nyias nyias ntawm tes; ions uas teeb liab hauv thiab nruab nrab ntawm cov cellular compartments; thiab roj thiab dawb radicals uas tuaj yeem ua rau pom thoob plaws ntawm tes thiab

Cov tshuaj hormones twg siv cov tub txib thib ob?

Piv txwv ntawm cov tshuaj hormones uas siv cAMP ua tus tub txib thib ob suav nrog calcitonin, uas yog qhov tseem ceeb rau kev tsim cov pob txha thiab tswj cov qib calcium hauv cov ntshav; glucagon, uas ua lub luag haujlwm hauv cov ntshav qabzib; thiab cov thyroid stimulating tshuaj hormone , uas ua rau kev tso tawm T3 thiab T.4 los ntawm cov thyroid caj pas.

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