Qhov ntim zoo ntawm kev faib khoom yog dab tsi?

2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44

Yog tias qhov ntim ntawm 7 4 thiab 15 7 l ua , cov tshuaj tau xav kom faib thoob plaws hauv cov ntshav (ntshav thiab cov qe ntshav liab). Yog tias qhov ntim ntawm kev faib tawm loj dua 42, cov tshuaj xav tau muab faib rau tag nrho cov ntaub so ntswg hauv lub cev, tshwj xeeb tshaj yog cov nqaij rog.

Hais txog qhov no, qhov ntim ntawm kev faib txhais li cas?

Hauv pharmacology, cov ntim faib (V_D, tseem paub tias pom tseeb ntim faib ) yog theoretical ntim uas yuav yuav tsum muaj tag nrho cov nyiaj ntawm cov tshuaj uas tau muab coj los ua tib zoo saib xyuas hauv cov ntshav ntshav.

Tsis tas li ntawd, vim li cas qhov ntim ntawm kev faib khoom tseem ceeb? Cov ntim faib muaj txiaj ntsig zoo hauv kev kwv yees koob tshuaj uas yuav tsum tau ua kom tau txais cov ntshav ntshav zoo li A = C · Vd, nrog A = tus nqi tshuaj hauv lub cev (≈ koob tshuaj, tsis ntev tom qab kev tswj hwm) thiab C = ntshav siab. Kev hloov pauv ntawm Vd feem ntau cuam tshuam rau qhov siab tshaj plaws plasma concentration ntawm cov tshuaj.

Ntxiv rau qhov no, qhov ntim qis ntawm kev faib tawm txhais li cas?

Txhais /Introduction Conversely, ib tug tshuaj nrog a qis Vd muaj kev xav kom nyob twj ywm hauv cov ntshav lub ntsiab lus a qis dua yuav tsum tau txhaj cov tshuaj kom ua tiav cov ntshav plasma concentration. ( Tsawg Vd -> Less faib mus rau lwm cov ntaub so ntswg)

Yam dab tsi cuam tshuam rau qhov ntim ntawm kev faib tawm?

Cov yam ntxwv ntawm tus neeg mob tuaj yeem suav nrog hnub nyoog , poj niam txiv neej, cov leeg nqaij, rog rog thiab cov kua dej txawv txav (oedema, ascites, pleural effusion). Cov tshuaj yam tseem ceeb yuav suav nrog cov ntaub so ntswg khi, plasma protein binding thiab physicochemical zog ntawm cov tshuaj (qhov loj, nqi, pKa, lipid solubility, dej solubility).