Video: Atropine pab nrog cholinesterase inhibitors li cas?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Atropine kev sib tw txwv cov teebmeem ntawm cholinesterase inhibitors ntawm muscarinic, tab sis tsis yog nicotinic cholinergic receptors. Cov koob tshuaj loj heev atropine tej zaum yuav tsim nyog rau tshuaj lom vim yog kev tua tus kheej ntawm cov tshuaj tua kab organophosphorus.
Ib yam nkaus, qhov kev txiav txim ntawm cov tshuaj atropine yog dab tsi?
Pharmacodynamics. Atropine txo cov qog nqaij hlav hauv qhov ncauj thiab cov hlab ntsws, txo qhov constriction thiab spasm ntawm cov hlab ntsws, thiab tuaj yeem txo cov leeg tuag tes tuag taw, uas tshwm sim los ntawm kev ua ntawm cov tshuaj lom neeg ntawm lub hauv nruab nrab paj hlwb.
Qhov thib ob, cholinesterase inhibitors ua dab tsi? Cholinesterase inhibitors (tseem hu ua acetylcholinesterase inhibitors ) yog ib pawg ntawm cov tshuaj uas thaiv qhov kev ua txhaum ntawm acetylcholine ib txwm. Acetylcholine yog lub ntsiab neurotransmitter pom nyob rau hauv lub cev thiab muaj zog nyob rau hauv ob qho tib si lub paj hlwb peripheral thiab lub hauv paus paj hlwb.
Tom qab ntawd, ua li cas atropine ua haujlwm hauv tshuaj lom organophosphate?
Pralidoxime (2-PAM) tuaj yeem tiv thaiv tau organophosphate lom vim nws tuaj yeem rov tshem tawm qhov phosphorylation no. Atropine tuaj yeem siv los txo cov nyhuv ntawm cov lom los ntawm thaiv muscarinic acetylcholine receptors, uas yuav txwv tsis pub siv ntau dhau, los ntawm kev tso zis ntau dhau acetylcholine.
Dab tsi ua atropine ua rau muscarinic receptors?
Atropine yog a muscarinic receptor antagonist uas yog siv los inhibit qhov cuam tshuam ntawm kev ua kom ntau dhau ntawm vagal ntawm lub plawv, uas yog tshwm sim raws li sinus bradycardia thiab AV nodal block.
Pom zoo:
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