![Yuav muaj dab tsi tshwm sim thaum cov tshuaj hla txoj hlab ntshav lub hlwb? Yuav muaj dab tsi tshwm sim thaum cov tshuaj hla txoj hlab ntshav lub hlwb?](https://i.answers-medical.com/preview/medical-health/14113973-what-happens-when-a-drug-crosses-the-blood-brain-barrier-j.webp)
Video: Yuav muaj dab tsi tshwm sim thaum cov tshuaj hla txoj hlab ntshav lub hlwb?
![Video: Yuav muaj dab tsi tshwm sim thaum cov tshuaj hla txoj hlab ntshav lub hlwb? Video: Yuav muaj dab tsi tshwm sim thaum cov tshuaj hla txoj hlab ntshav lub hlwb?](https://i.ytimg.com/vi/dQoUkurokk0/hqdefault.jpg)
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Los ntawm kev txo cov kev txwv ntawm cov thaiv , nws yog qhov yooj yim dua kom tau txais cov molecule kom dhau los ntawm nws. Cov no tshuaj nce lub permeability ntawm lub ntshav – hlwb barrier ib ntus los ntawm kev nce osmotic siab hauv ntshav uas loosens cov junctions nruj ntawm lub endothelial hlwb.
Ib yam li ntawd, yuav ua li cas cov tshuaj hla cov hlab ntsha hauv hlwb?
BBB yog anatomically thiab functionally txawv ntawm tus ntshav - cerebrospinal kua thaiv ntawm choroid plexus. Qee yam me me tshuaj tej zaum tus ntoo khaub lig BBB ntawm lipid-mediated dawb diffusion, muab cov tshuaj muaj qhov hnyav molecular <400 Da thiab ua <8 hydrogen bonds.
Qhov thib ob, yam tshuaj tua kab mob twg hla cov ntshav hauv lub hlwb? Txawm li cas los xij, muaj ntau cov tshuaj tua kab mob lipophilic tab sis cov tshuaj tua kab mob feem ntau siv yog ampicillin, cefotaxime, ceftriaxone, gentamicin sulfate, penicillin G thiab vancomycin.
Tom qab ntawd, ib tus tuaj yeem nug, vim li cas cov tshuaj feem ntau yuav tuaj yeem hla cov hlab ntsha hauv lub hlwb?
Muaj yog ob peb mechanisms uas tshuaj tuaj yeem hla cov ntshav - hlwb barrier (BBB): 1. Kev txav mus los ntawm cov neeg ua dej-soluble thoob plaws BBB yog tsis tsim nyog vim yog kev sib tshuam nruj ntawm cov cell endothelial. Proteins, xws li albumin, yog adsorbed thiab thauj hla BBB los ntawm transcytosis.
Puas yog meropenem hla cov hlab ntsha hauv lub hlwb?
Meropenem Kev nkag mus thoob plaws BBB hauv Cov Neeg Mob Nrog CNS Kab Mob thiab Kev Txhim Kho ntawm Meropenem Kev kho mob. Cov ntsiab lus luv luv: Meropenem yog ib qho tseem ceeb rau kev tswj hwm tom qab neurosurgical meningitis, tab sis cov ntaub ntawv hais txog nws nkag mus thoob plaws ntshav - hlwb barrier (BBB) tsis txaus.
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