Video: Vim li cas pulmonary vasoconstriction tshwm sim hauv hypoxia?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Hypoxia ua txwv hauv me me ntsws cov hlab ntsha thiab dilatation nyob rau hauv cov hlab ntsha systemic. Hauv ob lub cell, ua hypoxia tau pom tias inhibit ib qho poov tshuaj sab nraud tam sim no, yog li ua rau daim nyias nyias depolarization thiab calcium nkag los ntawm qhov voltage-dependent calcium channels.
Tsis tas li ntawd, ua li cas hypoxia ua rau pulmonary hypertension?
Txhawm rau kom ntseeg tau tias kev xa oxygen los ntawm lub ntsws mus rau cov ntshav muaj txiaj ntsig zoo li sai tau, lub cev hloov cov ntshav ntws mus rau thaj tsam ntawm lub ntsws nrog cov pa oxygen ntau dua. Qhov no ua tau coj mus caws pliav, uas nqaim thiab stiffens cov hlab ntsha thiab ua rau cov ntshav siab ntau dua.
Kuj Paub, dab tsi cuam tshuam hypoxic pulmonary vasoconstriction? Qhov stimulus rau HPV feem ntau yog alveolar oxygen nro (PAO2), uas stimulates precapillary vasoconstriction kev faib tawm ntsws Cov ntshav ntws tawm ntawm thaj chaw hypoxemic ntawm lub ntsws los ntawm txoj hauv kev uas tsis muaj lossis cyclooxygenase synthesis inhibition . HPV muaj ib tug biphasic temporal teb rau alveolar ua hypoxia.
Tib neeg kuj nug, dab tsi ua rau pulmonary artery constriction?
Nyob rau hauv cov ntaub ntawv ntawm cov hlab ntsws , txwv yog tshwm sim los ntawm: (i) calcium tso tawm los ntawm cov leeg nqaij sarcoplasmic reticulum thiab lub khw-depletion-activated calcium nkag mus rau hauv cov leeg nqaij leeg thiab, (ii) kev hloov pauv ntawm kev tso tawm los ntawm cov pulmonary leeg endothelium, uas ua rau
Puas yog hypoxia tuaj yeem ua rau mob ntsws ntsws?
Alveolar hypoxia ua rau pulmonary edema cuam tshuam nrog kev nce siab hauv lub ntsws capillary thiab txo qis alveolar kua reabsorption. Txawm li cas los xij, lub luag haujlwm ntawm kev hloov pauv permeability tsis meej.
Pom zoo:
Qhov twg ntawm cov hauv qab no yog qhov muaj peev xwm tshwm sim tshwm sim ntawm kev tswj hwm procainamide?
Muaj ntau cov kev mob tshwm sim tom qab induction ntawm procainamide. Cov kev tsis zoo no yog ventricular dysrhythmia, bradycardia, hypotension thiab poob siab. Cov kev phom sij tshwm sim ntau dua yog tias cov koob tshuaj txhua hnub tau nce. Procainamide kuj tseem tuaj yeem ua rau kub cev tshuaj thiab lwm yam kev ua xua
Dab tsi yog qhov tshwm sim tshwm sim ntawm tus neeg sawv cev tiv thaiv anginal?
Mob taub hau yog qhov tshwm sim feem ntau ntawm nitrates; feem ntau cuam tshuam nrog koob tshuaj thiab tshaj tawm txog li 82% ntawm cov neeg mob hauv kev sim tshuaj tswj cov placebo. Ze li 10% ntawm cov neeg mob tsis tuaj yeem tiv taus nitrates vim ua rau mob taub hau lossis kiv taub hau
Dab tsi yog ob qhov tshwm sim tshwm sim ntau tshaj ntawm cov tshuaj bronchodilators?
Cov tshuaj bronchodilators tuaj yeem muaj cov kev mob tshwm sim zoo li no: Ntshai lossis tshee tshee. Nce lub plawv dhia los yog palpitations. Chim plab. Teeb meem pw tsaug zog. Cov leeg mob los yog cramps
Dab tsi ntawm cov hauv qab no yog qhov tshwm sim ntawm pulmonary embolism?
Pulmonary embolus feem ntau tshwm sim los ntawm cov ntshav txhaws uas tshwm sim hauv cov hlab ntsha sab nraud ntawm lub ntsws. Cov ntshav ntau tshaj plaws yog ib qho nyob rau hauv cov leeg sib sib zog nqus ntawm tus ncej puab lossis hauv lub plab (thaj chaw hauv siab). Hom kab mob no hu ua Deep vein thrombosis (DVT)
Kev mob hnyav hypoxia tshwm sim li cas nrog mob ntsws?
Yuav ua li cas mob hnyav hypoxia nrog mob ntsws? Acidosis depresses ua pa. Oxygen diffusion yog impaired los ntawm congestion. Inflammatory exudate absorbs oxygen los ntawm huab cua alveolar