Video: Puas yog penicillin inhibit protein synthesis?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Penicillin , ib qho ntawm thawj cov tshuaj tua kab mob siv dav, tiv thaiv cov kauj ruam kawg ntawm kev sib txuas, lossis transpeptidation, hauv kev sib dhos ntawm cov macromolecule no. Lwm hom tshuaj tua kab mob-tetracycline-ib yam txwv kab mob loj hlob los ntawm kev nres protein synthesis.
Tib neeg kuj nug, dab tsi tshuaj tua kab mob inhibit protein synthesis?
Cov tshuaj tua kab mob tuaj yeem tiv thaiv kev sib txuas ntawm cov protein los ntawm kev tsom mus rau 30S subunit, piv txwv xws li spectinomycin, tetracycline, thiab aminoglycosides kanamycin thiab streptomycin, lossis mus rau 50S subunit, piv txwv ntawm uas suav nrog clindamycin , chloramphenicol , linezolid thiab macrolides erythromycin tshuaj , Tsis tas li ntawd, cov tshuaj tua kab mob cuam tshuam li cas rau kev tsim cov protein? Txhua tus tshuaj tua kab mob lub hom phiaj kab mob protein synthesis ua Yog li los ntawm kev cuam tshuam nrog cov kab mob ribosome thiab inhibiting nws txoj haujlwm. Lub ribosome yuav tsis zoo li lub hom phiaj zoo rau kev xaiv toxicity, vim hais tias txhua lub hlwb, nrog rau peb tus kheej, siv ribosomes rau protein synthesis.
Ib yam nkaus, penicillin tuaj yeem tiv thaiv kab mob loj hlob li cas?
Penicillin tua kab mob los ntawm kev khi ntawm lub nplhaib beta-lactam rau DD-transpeptidase, inhibiting nws txoj haujlwm hla kev sib txuas thiab tiv thaiv kev tsim phab ntsa ntawm tes tshiab. Lub cell phab ntsa ntawm gram-negative kab mob tau nyob ib puag ncig los ntawm lipopolysaccharide (LPS) txheej ntau dua tiv thaiv cov tshuaj tua kab mob nkag mus rau hauv lub cell.
Penicillin inhibit peptidoglycan synthesis li cas?
Penicillin irreversibly thaiv cov kab mob cell phab ntsa synthesis los ntawm inhibiting tsim ntawm peptidoglycan hla-txuas. Cov kab mob no muaj beta-lactamases, chav kawm dav dav ntawm cov enzymes nrog serine seem uas tshem tawm cov reactive beta lactam nplhaib los ntawm acyl-enzyme nruab nrab.
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