Video: TCR ntau haiv neeg tsim tau li cas?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
TCR ntau yam yog tsim tawm los ntawm kev hloov pauv tsis raug thiab tsis meej ntawm V thiab J ntu ntawm TCR alpha (TCRA) thiab V, D, thiab J ntu ntawm TCR beta (TCRB) noob nyob rau hauv thymus. Thymic zus tau tej cov T hlwb yog ib tug mechanism rau tsim kom muaj ntau haiv neeg TCR.
Tib neeg kuj nug, pes tsawg TCR nyob ntawm tes?
Muaj kwv yees li 105 TCRs tau qhia rau saum npoo ntawm cytotoxic T lymphocyte (CTL), thiab nws tau pom tias kev koom tes ntawm txhua qhov chaw ntawm 3- 400 TCRs ntawm ib lub xov tooj yuav txaus rau kev ua kom CTL (42, 7, 3).
Qhov thib ob, TCR khi rau dab tsi? Lwm cov ntaub ntawv. Locus. Chr. 7 np14. T-cell receptor ( TCR ) yog Ib qho molecule pom nyob rau saum npoo ntawm T cells, lossis T lymphocytes, uas yog Lub luag hauj lwm rau kev lees paub qhov tawg ntawm antigen li peptides khi rau loj histocompatibility complex (MHC) molecules.
Ua li no, TCR yog dab tsi thiab lawv zoo li cov tshuaj tiv thaiv li cas?
T-cell-receptor- zoo li cov tshuaj tiv thaiv - tiam, kev ua haujlwm thiab kev siv. Cov tshuaj tiv thaiv no , npe TCR - zoo li cov tshuaj tiv thaiv , tau raug tsim los ua chav kawm tshiab ntawm kev kho tshuaj tiv thaiv kab mob uas tuaj yeem tsom mus rau cov qog thiab cov kab mob sib kis ntawm cov cell thiab kho kom haum lawv qhov kev tua tshwj xeeb.
TCR kev kho dua tshiab tshwm sim nyob qhov twg?
V(D)J recombination tshwm sim hauv thawj cov qog ntshav hauv lub cev (pob txha pob txha rau B cells thiab thymus rau T cells) thiab nyob rau hauv qhov yuav luag ib txwm zam rov qab hloov pauv qhov sib txawv (V), koom nrog (J), thiab qee qhov, muaj ntau haiv neeg (D) cov noob ntu.
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