Video: NK cells ua haujlwm li cas?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
NK cev muab cov lus teb sai rau tus kab mob hlwb , ua yeeb yam nyob ib ncig ntawm 3 hnub tom qab kis kab mob, thiab teb rau cov qog tsim. Feem ntau, tiv thaiv kab mob hlwb kuaj xyuas qhov loj histocompatibility complex (MHC) uas nthuav tawm ntawm tus kab mob ntawm tes nto, ua rau cytokine tso tawm, ua rau lysis lossis apoptosis.
Xav txog qhov no, NK cells tua li cas?
Ntuj killer ( NK ) hlwb sib aim thiab tua tsis ncaj ncees lawm hlwb , xws li kis tus kab mob virally thiab tumorigenic hlwb . Tua yog kho nruab nrab los ntawm cytotoxic molecules uas tau khaws cia hauv cov lysosomes secretory, tshwj xeeb exocytic organelle pom hauv NK hlwb.
puas yog NK cells T cells? Ntuj killer ( NK ) T hlwb yog ib pawg ntawm T hlwb uas qhia TCR αβ chains nrog rau ntau yam NK cell cov cim (Rhost li al., 2012; Kumar thiab Delovitch, 2014). Cov no hlwb lees paub ob qho tib si exogenous thiab endogenous lipid antigens hauv cov ntsiab lus ntawm MHC-zoo li molecule CD1d.
Hauv qhov no, kuv yuav qhib NK cells li cas?
NK hlwb yog ib yam qhib los ntawm immunoreceptor tyrosine-based ua haujlwm motifs (ITAMs) los yog inhibited los ntawm immunoreceptor tyrosine-based inhibitory motifs hauv lawv cov cytoplasmic tails. Kev txhim kho ntawm NK hlwb nyob rau hauv yuav tsum muaj kev sib cuam tshuam ntawm ob qho tib si MHC-I thiab inhibiting receptors.
Ntev npaum li cas cov neeg tua neeg tuag nyob?
Ciaj sia ntawm kev paub tab NK cev yog cytokine nyob; Hauv cov nas, interleukin (IL)-15 zoo li ua kom muaj sia nyob ntev ntawm cov tshuaj antiapoptotic Bcl-2. Txais kev sim hloov pauv thiab ntev -term BrdU cov kev tshawb fawb hauv nas tau qhia pom luv luv ncig ib nrab- nyob txog li 7-10 hnub rau kev paub tab NK hlwb.
Pom zoo:
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