Puas yog milbemycin oxime yog macrocyclic lactone?

2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44

Muaj kev lag luam milbemycins yog milbemycin oxime thiab moxidectin. Cov macrocyclic lactones muaj lub zog loj, nthuav dav antiparasitic spectrum ntawm qib qis. Lawv nquag tawm tsam ntau yam tsis paub qab hau nematodes (xws li hypobiotic larvae) thiab arthropods.

Xav txog qhov no, macrocyclic lactones ua haujlwm li cas?

Macrocyclic lactones ua raws li GABA agonists thiab kuj khi rau glutamate-gated chloride raws hauv cov hlab ntsha thiab cov leeg nqaij ntawm cov invertebrates. Nyob rau hauv ob qho tib si, cov kev ua no thaiv kev sib kis ntawm neuronal signals ntawm parasites, uas yog txawm tuag tes tuag taw thiab ntiab tawm ntawm lub cev, los yog tshaib plab helmints.

Tsis tas li ntawd, puas yog milbemycin oxime muaj kev nyab xeeb rau kev sib tsoo? Qee hom tsiaj, xws li cov collies , yaj yaj, thiab collie - lossis cov tsiaj yug tsiaj yug tsiaj, muaj kev nkag siab rau tsuas yog siv me ntsis ntawm milbemycin thiab tej zaum yuav muaj kev phiv tshuaj tsawg dua. Cov tshuaj uas ua haujlwm nruab nrab no yuav tsum tsis ua haujlwm li ob peb hnub, txawm hais tias cuam tshuam ntev npaum li cas hauv cov tsiaj nrog mob siab lossis mob raum.

Ib yam li ntawd, koj tuaj yeem nug, macrocyclic lactone anthelmintic yog dab tsi?

Cov macrocyclic lactone tsev neeg ntawm anthelmintic Cov tshuaj (MLs) suav nrog ivermectin, tib tus tswv cuab tam sim no tau pom zoo siv rau tib neeg, selamectin, moxidectin thiab milbemycin oxime. Tag nrho cov no yog siv los tswj cov kab mob tshwm sim los ntawm filarial nematodes.

Puas yog moxidectin yog avermectin?

Qhov kev tshuaj xyuas no yuav tsom mus rau kev sib piv ntawm moxidectin (MOX), ib tug tswv cuab ntawm milbemycin subfamily ntawm MLs, thiab cov tshuaj avermectin subfamily ntawm MLs siv hauv tsiaj thiab tib neeg. Cov avermectins tau muab los ntawm cov kab mob hauv av Streptomyces avermitilis, xaiv raws cov tshuaj tua kab thiab tshuaj tua kab mob.