Video: Puas yog tib neeg muaj dihydrofolate reductase?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Dihydrofolate reductase . Hauv tib neeg , cov DHFR enzyme yog encoded los ntawm DHFR noob. Nws tau pom nyob hauv thaj tsam q11 → q22 ntawm chromosome 5. Cov kab mob muaj cov yam ntxwv sib txawv DHFR enzymes (raws li lawv cov qauv ntawm kev khi diaminoheterocyclic molecules), tab sis mammalian DHFRs yog zoo sib xws.
Raws li, dihydrofolate reductase ua dab tsi?
Dihydrofolate reductase yog ib qho enzyme me uas ua lub luag haujlwm txhawb nqa, tab sis yog lub luag haujlwm tseem ceeb, hauv kev tsim cov DNA thiab lwm yam txheej txheem. Nws tswj hwm lub xeev ntawm folate, ib qho tshuaj tsw qab organic molecule uas kaw cov pa roj carbon atoms rau cov enzymes uas xav tau lawv hauv lawv cov kev cuam tshuam.
Tom qab ntawd, lo lus nug yog, hom tshuaj tiv thaiv dab tsi yog methotrexate? 1 Methotrexate. Methotrexate yog folic acid analogue siv los kho ntau yam kev mob qog noj ntshav thiab mob qog noj ntshav. Nws yog ib qho kev sib tw inhibitor ntawm dihydrofolate reductase , thaiv qhov kev hloov pauv ntawm dihydrofolate hmoov rau tetrahydrofolate thiab inhibiting cellular tu tub tu kiv.
Thiaj li, DHFR yog dab tsi thiab vim li cas nws thiaj tseem ceeb?
Dihydrofolate Reductase ( DHFR ) yog heev tseem ceeb enzyme vim tias nws tsim cofactors uas tsim nyog rau kev sib txuas DNA. THF yog ib qho tseem ceeb cofactor koom nrog hauv kev hloov pauv ntawm methyl, methylene, thiab formyl pawg los ntawm ib qho molecule mus rau lwm lub sijhawm thaum tsim cov nucleotides thiab ntau cov amino acids.
Yuav ua li cas methotrexate cuam tshuam nrog DHFR?
Nws xav tias cuam tshuam mob qog noj ntshav thiab mob caj dab rheumatoid los ntawm ob txoj hauv kev sib txawv. Rau mob qog noj ntshav, methotrexate txwv kev sib tw dihydrofolate reductase ( DHFR ), ib qho enzyme uas koom nrog hauv tetrahydrofolate synthesis. Affinity ntawm methotrexate rau DHFR yog li 1000-npaug ntawm cov folate.
Pom zoo:
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