Video: Puas yog BRCA noob yog tus tiv thaiv qog nqaij hlav lossis proto oncogene?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Proto - cov oncogenes tau xav ua lub luag haujlwm me me hauv kev tau txais txiaj ntsig mob qog noj ntshav syndromes, tshwj tsis yog RET raws - oncogene cov ntau yam endocrine neoplasia (MEN-II). Tumor suppressor noob yog chav kawm thib ob ntawm noob ib qho tseem ceeb rau kev tswj kev loj hlob ib txwm muaj. BRCA1 thiab BRCA 2 yog xav ua raws li noob suppressor noob.
Raws li, yog BRCA yog cov qog nqaij hlav qog?
BRCA1 . BRCA1 yog tib neeg noob suppressor noob (tseem hu ua tus saib xyuas noob ) thiab yog lub luag haujlwm kho DNA. BRCA1 thiab BRCA2 tsis cuam tshuam nrog cov protein, tab sis ob qho tib si feem ntau tau hais tawm hauv cov hlwb ntawm lub mis thiab lwm cov ntaub so ntswg, qhov uas lawv pab kho DNA puas, lossis rhuav tshem cov cell yog tias DNA tsis tuaj yeem kho tau.
Ib qho ntxiv, puas yog cov qog nqaij hlav suppressor noob caj noob ces proto oncogenes? Dominant gain-of-function mutations nyob rau hauv cov protooncogenes thiab kev poob qis ntawm kev ua haujlwm hloov pauv hauv qog - noob noob suppressor yog oncogenic ua . Ib qho qhib kev hloov pauv ntawm ib ntawm ob tus alleles ntawm a raws - oncogene cov hloov nws mus rau ib qho oncogene cov , uas tuaj yeem ua rau hloov pauv hauv cov kab lis kev cai los yog mob qog noj ntshav hauv tsiaj.
Dhau li, puas yog p53 yog proto oncogene lossis qog nqaij hlav suppressor noob?
Cov txheej txheem kev faib tawm siv los txheeb xyuas ntau yam noob caj noob ces kaw qog protein ntau p53 ua (TP53) rau lub luag haujlwm ntawm a noob suppressor noob . Txawm li cas los xij, tam sim no nws yog qhov tsis txaus ntseeg qhov tseeb uas ntau p 53 ib mutants ua raws li oncogenic ua cov protein.
Dab tsi yog oncogenes thiab Tumor suppressor noob?
Ob chav kawm ntawm noob , oncogenes thiab cov qog nqaij hlav suppressor noob , txuas xovtooj ntawm tes tswj mus qog tsim thiab kev loj hlob. Tumor suppressor noob ntawm qhov tod tes, txwv kev loj hlob ntawm tes. Lawv kev tswj hwm kev faib xovtooj ntawm tes ploj nrog caj ces kev hloov pauv ua rau lawv tsis ua haujlwm.
Pom zoo:
Yuav ua li cas feem pua ntawm cov qog nqaij hlav qog nqaij hlav qog noj ntshav?
Kev Kho Mob: Kev kho hluav taws xob
Puas yog qog pituitary suav tias yog qog nqaij hlav hauv hlwb?
Ib qho qog uas tsim nyob rau hauv lub caj pas pituitary feem ntau suav tias yog hom mob qog noj ntshav hauv lub hlwb. Thaum lub caj pas pituitary tsis ua los ntawm cov ntaub so ntswg, nws txuas ncaj qha rau ib feem ntawm lub hlwb hu ua hypothalamus
Puas yog cov qog nqaij hlav qog nqaij hlav nyuaj?
Shotty feem ntau siv los piav txog qhov kev xav ntawm cov qog nqaij hlav (cov qog qog nqaij hlav) thaum lawv palpated (xws li) los ntawm daim tawv nqaij. 'Shotty' lymph nodes yog cov uas tsis yog nyuaj thiab puag ncig tab sis kuj me me thiab tsis muaj qhov tshwm sim
Puas yog qog nqaij hlav qog lossis cov qog ua kua?
Ib qho txawv txav ntawm cov ntaub so ntswg uas feem ntau tsis muaj cov hlwv lossis cov kua dej. Cov qog nqaij hlav tuaj yeem yog benign (tsis yog mob qog noj ntshav), lossis malignant (cancer). Piv txwv ntawm cov qog nqaij hlav yog sarcomas, carcinomas, thiab lymphomas. Leukemias (cov ntshav qog ntshav) feem ntau tsis tsim cov qog nqaij hlav
Puas yog p53 yog proto oncogene lossis cov qog nqaij hlav suppressor?
Cov txheej txheem kev faib tawm siv los txheeb xyuas ntau yam kab mob qog noj ntshav tau txwv cov qog nqaij hlav protein p53 (TP53) rau lub luag haujlwm ntawm cov qog qog nqaij hlav. Txawm li cas los xij, tam sim no nws yog qhov tsis txaus ntseeg qhov tseeb uas ntau tus p53 hloov pauv ua raws li cov protein oncogenic