Video: Puas yog p53 yog proto oncogene lossis cov qog nqaij hlav suppressor?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Cov txheej txheem kev faib tawm siv los txheeb xyuas ntau yam kab mob qog noj ntshav kaw qog protein ntau p53 ua (TP53) rau lub luag haujlwm ntawm a qog suppressor gene . Txawm li cas los xij, tam sim no nws yog qhov tseeb indisputable uas ntau p53 ua mutants ua raws li oncogenic ua cov protein.
Hauv qhov no, puas yog p53 yog cov qog nqaij hlav qog?
p53 ua , tseem hu ua TP53 lossis qog protein (EC: 2.7. 1.37) yog a noob uas cim rau cov protein uas tswj hwm lub voj voog ntawm tes thiab yog li ua haujlwm zoo li qog nqaij hlav.
Qhov thib ob, qhov txawv ntawm proto oncogenes thiab qog suppressor noob yog dab tsi? Ib qho tseem ceeb qhov sib txawv ntawm oncogenes thiab qog suppressor noob yog tias cov oncogenes tshwm sim los ntawm kev ua kom (tig rau) ntawm raws - cov oncogenes , tab sis qog suppressor noob ua rau mob qog noj ntshav thaum lawv inactivated (tua tawm). Lawv ua rau tej yam mob qog noj ntshav khiav hauv tsev neeg.
Ntxiv mus, puas yog p53 proto oncogene?
Cov p53 ua - oncogene tuaj yeem ua tus tiv thaiv kev hloov pauv. Qhov tsis tshua muaj clones ntawm hloov pauv foci uas tshwm sim los ntawm E1A ntxiv rau ras ntxiv rau hom tsiaj qus p53 ua triple transfections tag nrho muaj cov p53 ua DNA hauv lawv cov genome, tab sis feem coob tsis tau qhia txog qhov p53 ua protein ntau.
Puas yog BRCA gene yog qog nqaij hlav lossis proto oncogene?
Proto - cov oncogenes tau xav tias yuav ua si me me hauv cov kab mob qog noj ntshav, tshwj tsis yog RET raws - oncogene nyob rau hauv ntau yam endocrine neoplasia (MEN-II). Tumor suppressor noob yog cov chav kawm thib ob ntawm noob ib qho tseem ceeb rau kev tswj kev loj hlob. BRCA1 thiab BRCA 2 yog xav ua raws li qog suppressor noob.
Pom zoo:
Yuav ua li cas feem pua ntawm cov qog nqaij hlav qog nqaij hlav qog noj ntshav?
Kev Kho Mob: Kev kho hluav taws xob
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