Vim li cas cov hlwb hauv MM Tumors raug rhuav tshem los ntawm kev tiv thaiv kab mob?
Vim li cas cov hlwb hauv MM Tumors raug rhuav tshem los ntawm kev tiv thaiv kab mob?

Video: Vim li cas cov hlwb hauv MM Tumors raug rhuav tshem los ntawm kev tiv thaiv kab mob?

Video: Vim li cas cov hlwb hauv MM Tumors raug rhuav tshem los ntawm kev tiv thaiv kab mob?
Video: Xov Xwm 03/19/2022: Russia & Ukraine Tsov Rog Hnub 24 Nrog Kev Sib Tham Ntawm Teb Chaws Mekas&Suav 2024, Lub Xya hli ntuj
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MM yog tshwm sim los ntawm faulty receptor protein nyob rau hauv ntawm tes - nto membranes. Cov cell hauv MM qog tuaj yeem ua rhuav tshem los ntawm kev tiv thaiv kab mob.

Tom qab ntawd, ib tus tuaj yeem nug, qhov qog tiv thaiv kab mob yog dab tsi?

1. Kev khiav tawm Tiv thaiv kab mob Kev lees paub los ntawm Poob Antigen Expression. Tiv thaiv kab mob teb rau qog cov cell faib cov kev xaiv uas ua rau muaj sia nyob thiab nthuav dav ntawm kev hloov pauv qog cov cell nrog txo cov tshuaj tiv thaiv kab mob, txheej txheem uas tau raug hu ua qog kev tiv thaiv kab mob.

Tom qab ntawd, lo lus nug yog, hom kev tiv thaiv kab mob dab tsi tau hu los ntawm Tumours? Hloov kho tiv thaiv kab mob rau qog tau kho kom haum xeeb los ntawm CD3+T-cell receptor (TCR+) T hlwb thaum lawv paub qog -derived peptides khi rau tus kheej-MHC molecules qhia ntawm APCs.

Tom qab ntawd, lub cev tiv thaiv kab mob ua dab tsi rau mob qog noj ntshav?

Mob qog noj ntshav tsis muaj zog lub tiv thaiv kab mob los ntawm kev kis mus rau cov pob txha pob txha. Cov pob txha pob txha ua rau cov qe ntshav uas pab tiv thaiv kab mob. Qhov no tshwm sim feem ntau hauv leukemia lossis lymphoma, tab sis nws tau tshwm sim nrog lwm yam mob qog noj ntshav ib yam nkaus. Cov mob qog noj ntshav txwv tsis pub cov pob txha pob txha los ntawm kev ua ntau cov qe ntshav.

T cells paub txog mob qog noj ntshav li cas?

T hlwb , uas yog tiv thaiv kab mob hlwb tseem ceeb heev rau kev tsis lees paub cov qog, siv lawv cov TCRs rau paub luv antigenic peptides khi rau MHC -I thiab -II cov lwg me me nyob saum npoo ntawm tus tswv APCs. Qhib qhib T hlwb tuaj yeem mus txuas ntxiv txhawm rau rhuav tshem antigen-positive host hlwb , piv txwv li, hlwb kis kab mob los yog mob qog noj ntshav.

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