Video: B cell affinity maturation tshwm sim nyob qhov twg?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Affinity maturation feem ntau tshwm sim ntawm qhov chaw tiv thaiv kab mob immunoglobulin ntawm lub hauv paus chaw B hlwb thiab raws li qhov tshwm sim ncaj qha ntawm somatic hypermutation (SHM) thiab xaiv los ntawm Tfh hlwb.
Hauv qhov no, B cell maturation yog dab tsi?
B lymphocytes los yog B hlwb tsim cov tshuaj tiv thaiv koom nrog hauv kev tiv thaiv humoral. B hlwb yog tsim nyob rau hauv cov pob txha pob txha, qhov twg thawj theem ntawm kev loj hlob tshwm sim, thiab taug kev mus rau tus po rau cov kauj ruam kawg ntawm kev loj hlob mus rau hauv naïve mature B hlwb . Nco B hlwb kuj tsim.
Tom qab ntawd, lo lus nug yog, qhov twg somatic hypermutation tshwm sim? Cov chaw nruab nrab ntawm cov kab mob peripheral lymphoid cov ntaub so ntswg yog cov chaw uas somatic hypermutation, zoo xaiv thiab sib txawv ntawm B hlwb nrog high-affinity receptors tshwm sim. Germinal cov chaw yog tib qhov chaw hauv lub cev uas muaj antigen khaws cia tau ntau lub hlis lossis xyoo nyob rau lwm qhov chaw.
Zoo ib yam tuaj yeem nug, yuav ua li cas B cells tau qhib?
B - hlwb yog qhib los ntawm kev khi ntawm antigen rau receptors ntawm nws ntawm tes nto uas ua rau lub ntawm tes los faib thiab loj hlob. Qee qhov txhawb nqa B - hlwb ua ntshav hlwb , uas secrete antibodies. Lwm tus ua lub cim xeeb ntev B - hlwb uas tuaj yeem ua rau lub sijhawm tom qab sib txawv rau hauv plasma hlwb.
Puas T cells puas muaj kev sib raug zoo?
Tsis zoo li BCR, tus T -cell receptor (TCR) ua tsis tau undergo affinity maturation . Txawm li cas los xij, antigen-primed T hlwb ua rau kom lawv cov tshuaj tiv thaiv kab mob zoo dua piv rau antigen-inexperienced (naïve) T hlwb nyob rau hauv tus txheej txheem hu ua functional avidity kev loj hlob.
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