Video: Dab tsi yog ntshav hlwb barrier?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Cov ntshav - hlwb teeb meem yog tsim los ntawm cov qog endothelial txwv tsis pub cov tshuaj los ntawm ntshav xaiv ntau dua li cov endothelial cells ntawm capillaries lwm qhov hauv lub cev. Ntau thaj chaw ntawm tib neeg lub hlwb tsis nyob ntawm lub hlwb sab ntawm BBB.
Ib yam li ntawd, nws tau nug, ntshav ntshav thaiv dab tsi thiab yog vim li cas thiaj tseem ceeb?
Cov ntshav - hlwb teeb meem (BBB) yog tsim los ntawm lub hlwb endothelial cells txheej hauv lub paj hlwb microvasculature, thiab yog ib qho tseem ceeb mechanism tiv thaiv lub lub hlwb los ntawm kev hloov pauv hauv cov ntshav muaj pes tsawg leeg, thiab los ntawm cov khoom siv sib xws xws li kev xa cov neurotransmitters thiab xenobiotics muaj peev xwm cuam tshuam kev ua haujlwm ntawm lub paj hlwb.
dab tsi tshuaj hla cov ntshav hlwb barrier? Cov ntawv hla ntawm cov khoom thoob plaws ntshav – hlwb teeb meem . (A) Passive diffusion: roj-soluble tshuaj yaj nyob rau hauv cell membrane thiab tus ntoo khaub lig cov thaiv (e.g., cawv, nicotine thiab caffeine). Cov dej-soluble tshuaj xws li penicillin muaj teeb meem hauv kev nkag mus.
Hauv qhov no, dab tsi tuaj yeem thiab Tsis tuaj yeem hla dhau qhov teeb meem ntawm lub hlwb?
Loj molecules tsis hla dhau BBB tau yooj yim. Tsawg lipid (fat) soluble molecules tsis nkag mus rau hauv lub hlwb . Txawm li cas los xij, lipid soluble molecules, xws li cov tshuaj barbituate, hla ceev ceev dhau rau hauv lub hlwb . Cov kua mis uas muaj hluav taws xob siab tau qeeb.
Cov khaubncaws sab nraud povtseg ntawm cov ntshav hauv lub hlwb yog dab tsi?
Txhua ntawm peb lub ntsiab CNS interface txheej: tus BBB , choroid plexus epithelium cov ntaub so ntswg thiab cov epithelium cov ntaub so ntswg ntawm arachnoid mater, ua haujlwm raws li lub cev, thauj, kev zom zaub mov, thiab kev tiv thaiv kab mob tiv thaiv kab mob. Cov teeb meem ua haujlwm tsis muaj zog thiab teb rau cov cai tswj hwm los ntawm ob qho tib si ntshav thiab lub hlwb.
Pom zoo:
Dab tsi tshuaj hla ntshav hlwb barrier?
Cov ntaub ntawv ntawm kev nkag mus ntawm cov khoom hla cov ntshav-hlwb barrier. (A) Passive diffusion: fat-soluble substances dissolve nyob rau hauv lub cell membrane thiab hla lub barrier (xws li, cawv, nicotine thiab caffeine). Cov dej-soluble tshuaj xws li penicillin muaj teeb meem nkag mus
Dab tsi glial cell yog lub luag hauj lwm rau cov ntshav hlwb barrier?
Fig. 3. Paracrine thiab autocrine regulation ntawm BBB thaum lub sij hawm homeostasis thiab o. Perivascular hlwb xws li pericytes thiab glial hlwb muaj kev cuam tshuam loj rau cov ntshav-hlwb barrier (BBB) ua haujlwm
Dab tsi yog 3 hom hlwb pob txha thiab lawv lub luag haujlwm yog dab tsi?
Cov pob txha tau tsim los ntawm peb hom cell hom: Osteoblasts, Osteocytes thiab Osteoclasts. Osteoblasts: Osteoblasts yog cov pob txha tsim cov hlwb uas nqis los ntawm cov hlwb osteoprogenitor. Osteocytes: Osteoclasts:
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