Video: Dab tsi tshuaj hla ntshav hlwb barrier?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Cov ntawv hla ntawm cov khoom thoob plaws ntshav – hlwb teeb meem . (A) Passive diffusion: roj-soluble tshuaj yaj nyob rau hauv cell membrane thiab tus ntoo khaub lig cov thaiv (e.g., cawv, nicotine thiab caffeine). Cov dej-soluble tshuaj xws li penicillin muaj teeb meem hauv kev nkag mus.
Yog li ntawd, yuav ua li cas tshwm sim thaum cov tshuaj hla cov hlab ntsha hauv lub hlwb?
Los ntawm kev txo cov kev txwv ntawm cov thaiv , nws yog qhov yooj yim dua kom tau txais cov molecule kom dhau los ntawm nws. Cov no tshuaj nce lub permeability ntawm lub ntshav – hlwb teeb meem ib ntus los ntawm kev nce osmotic siab hauv ntshav uas loosens cov junctions nruj ntawm lub endothelial hlwb.
Ib sab saum toj no, puas yog Opioids hla ntshav lub hlwb thaiv? Lub mechanism uas cov tshuaj opioids txo qhov mob thiab induce euphoria yog nyob ntawm cov tshuaj hla lub ntshav – hlwb teeb meem thiab nkag mus rau hauv nruab nrab paj hlwb. Qhov no qhia cov ntshav hlwb barrier ua lub luag haujlwm tseem ceeb hauv ob qho txiaj ntsig thiab kev pheej hmoo ntawm opioid siv.
Tom qab ntawd, ib tus tuaj yeem nug, vim li cas cov tshuaj feem ntau yuav tuaj yeem hla cov hlab ntsha hauv lub hlwb?
Muaj yog ob peb mechanisms uas tshuaj tuaj yeem hla cov ntshav - hlwb teeb meem (BBB): 1. Kev txav mus los ntawm cov neeg ua dej-soluble thoob plaws BBB yog tsis tsim nyog vim yog kev sib tshuam nruj ntawm cov cell endothelial. Proteins, xws li albumin, yog adsorbed thiab thauj hla BBB los ntawm transcytosis.
Puas yog tshuaj aspirin hla cov hlab ntsha hauv lub hlwb?
Cov kws tshawb fawb hais tias lawv tau tsim Tshuaj aspirin Uas Hla Lub Ntshav - Hlwb Teeb Meem . Cov ntshav - hlwb teeb meem zoo li daim ntaub thaiv uas ua rau cov kab mob tawm hauv lub hlwb ' ntshav muab, thiab tsuas yog tso cai rau dej, qee cov roj cua, thiab lipid-soluble molecules hla.
Pom zoo:
Dab tsi glial cell yog lub luag hauj lwm rau cov ntshav hlwb barrier?
Fig. 3. Paracrine thiab autocrine regulation ntawm BBB thaum lub sij hawm homeostasis thiab o. Perivascular hlwb xws li pericytes thiab glial hlwb muaj kev cuam tshuam loj rau cov ntshav-hlwb barrier (BBB) ua haujlwm
Dab tsi yog ntshav hlwb barrier?
Cov hlab ntsha-hlwb barrier yog tsim los ntawm endothelial cells txwv kev nkag mus ntawm cov tshuaj los ntawm cov ntshav ntau dua li cov hlwb endothelial ntawm capillaries lwm qhov hauv lub cev. Ntau qhov chaw ntawm tib neeg lub hlwb tsis nyob ntawm sab hlwb ntawm BBB
Cov kua ntshav ntshav yog dab tsi tom qab cov qe ntshav thiab cov ntshav khov tau raug tshem tawm?
Cov ntshav yog cov kua ntshav tom qab cov qe ntshav thiab cov protein sib xyaw tau raug tshem tawm. cov pa roj ntshav suav nrog oxygen, carbon dioxide, thiab nitrogen
Yuav muaj dab tsi tshwm sim thaum cov tshuaj hla txoj hlab ntshav lub hlwb?
Los ntawm kev txo qhov kev txwv ntawm qhov teeb meem, nws yooj yim dua kom tau txais cov molecule kom dhau los ntawm nws. Cov tshuaj no ua rau kom nkag mus tau yooj yim ntawm cov ntshav -lub hlwb teeb meem ib ntus los ntawm kev nce osmotic siab hauv cov ntshav uas xoob qhov sib txuas nruj ntawm cov cell endothelial
Puas yog cov tshuaj psychotropic hla cov ntshav lub hlwb teeb meem?
QHIA. Yuav kom ncav cuag lawv cov hom phiaj kho mob, cov tshuaj psychotropic yuav tsum hla cov ntshav-hlwb barrier. Txawm li cas los xij, cov tshuaj psychotropic uas muaj cov membrane permeability tsawg yuav xav tau cov membrane thauj mus rau hauv lub hlwb