Video: Cov tshuaj tiv thaiv dab tsi muaj nyob rau ntawm B hlwb?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Cov tshuaj tiv thaiv ntawm plasma cell muaj tib yam nkaus antigen -binding site thiab tshwj xeeb raws li lawv cov B cell precursors. Muaj tsib chav sib txawv ntawm cov tshuaj tiv thaiv pom nyob hauv tib neeg: IgM IgD, IgG , IgA , thiab IgE.
Hauv qhov no, puas yog B cells muaj cov tshuaj tiv thaiv ntawm lawv qhov chaw?
Cov tshuaj tiv thaiv , tseem hu ua immunoglobulins, yog glycosylated protein molecules tam sim no qhov chaw ntawm B hlwb ( nto immunoglobulins) ua hauj lwm raws li antigen receptors (BCR), los yog secreted rau hauv cov qhov chaw nyob sab nraud uas lawv tuaj yeem khi thiab ua kom nruab nrab lawv hom phiaj antigens (15).
Yuav ua li cas B hlwb tsim cov tshuaj tiv thaiv? Cov tshuaj tiv thaiv yog ua los ntawm cov ntshav dawb tshwj xeeb hlwb hu ua B lymphocytes (los yog B hlwb ). Thaum ib tug antigen khi rau lub B - ntawm tes nto, nws stimulates lub B cell los faib thiab paub tab rau hauv ib pawg uas zoo ib yam hlwb npe clone. Cov tshuaj tiv thaiv tua antigens los ntawm kev khi rau lawv.
Ua qhov no hauv kev txiav txim siab, hom tshuaj tiv thaiv kab mob twg ua B cells tsim?
Txhua B cell tsim ib hom kab mob antibody, txhua tus muaj qhov tshwj xeeb antigen - khi qhov chaw. Thaum lub ntsej muag lossis nco B cell tau qhib los ntawm antigen (nrog kev pab los ntawm tus pab T cell), nws proliferates thiab sib txawv rau hauv ib qho antibody-secreting effector cell.
Dab tsi yog kev sib raug zoo ntawm cov tshuaj tiv thaiv kab mob thiab B hlwb?
Thaum a B cell receptor khi nws cov cognate antigen (antigen ua rau qhov tshwj xeeb B cell ) nws hloov pauv thiab tuaj yeem zais ib daim ntawv soluble ntawm tus receptor. Daim ntawv soluble ntawm tus receptor yog hu ua ib qho tshuaj tiv thaiv . Cov tshuaj tiv thaiv yog tshwj xeeb rau cov antigen nws ntsib ntawm tus thawj B cell tus neeg txais kev pab.
Pom zoo:
Qhov twg ntawm cov tshuaj tiv thaiv hauv qab no yog siv rau kev txhaj tshuaj tiv thaiv kab mob?
Passive Immunization DISEASE NAME OF MATERIAL Cytomegalovirus Cytomegalovirus immun globulin, txhaj tshuaj tiv thaiv kab mob Diphtheria Diphtheria antitoxin, equine Rabies Rabies tiv thaiv globulin, tib neeg Measles Immune globulin, tib neeg
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Cov tshuaj tiv thaiv kab mob (immunoglobins) yog cov protein zoo li Y tsim los ntawm B hlwb ntawm lub cev tiv thaiv kab mob hauv kev teb rau kis rau antigens. Txhua cov tshuaj tiv thaiv muaj ib qho paratope uas paub txog ib qho epitope ntawm ib qho antigen, ua zoo li lub xauv thiab qhov tseem ceeb binding mechanism