Video: Puas yog cov tshuaj psychotropic hla cov ntshav lub hlwb teeb meem?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
QHIA. Txhawm rau kom ncav cuag lawv lub hom phiaj kho mob, cov tshuaj psychotropic yuav tsum hla cov ntshav - hlwb barrier . Txawm li cas los xij, cov tshuaj psychotropic uas muaj qis membrane permeability yuav tej zaum yuav xav tau ib tug membrane thauj mus rau hauv lub hlwb.
Xav txog qhov no, cov tshuaj dab tsi tuaj yeem hla cov hlab ntsha hauv hlwb?
Cov ntawv hla ntawm cov khoom thoob plaws ntshav – hlwb barrier . (A) Passive diffusion: roj-soluble tshuaj yaj nyob rau hauv cell membrane thiab ntoo khaub lig cov thaiv (e.g., cawv, nicotine thiab caffeine). Cov dej-soluble tshuaj xws li penicillin muaj teeb meem nkag mus.
Tsis tas li ntawd, cov tshuaj ionized tuaj yeem hla cov ntshav lub hlwb teeb meem? Cov tshuaj hla cov ntshav - hlwb barrier (BBB) los ntawm ntau yam txheej txheem. Cov no muaj xws li transmembrane diffusion, saturable transporters, adsorptive endocytosis, thiab txoj kev extracellular. Feem ntau tshuaj hauv kev siv tshuaj kho mob rau hnub tim yog me me, lipid soluble molecules uas ntoo khaub lig BBB los ntawm transmembrane diffusion.
Kuj tseem muaj lus nug, yuav muaj dab tsi tshwm sim thaum cov tshuaj hla cov ntshav hauv lub hlwb?
Los ntawm kev txo qis kev txwv ntawm thaiv , nws yog qhov yooj yim dua kom tau txais ib lub molecule kom dhau los ntawm nws. Cov no tshuaj nce lub permeability ntawm lub ntshav – hlwb barrier ib ntus los ntawm kev nce osmotic siab hauv cov ntshav uas loosens cov junctions nruj ntawm lub endothelial hlwb.
Puas yog meropenem hla ntshav lub hlwb teeb meem?
Meropenem Kev nkag mus thoob plaws BBB hauv Cov Neeg Mob Nrog CNS Kab Mob thiab Kev Txhim Kho ntawm Meropenem Kev kho mob. Cov ntsiab lus luv luv: Meropenem yog ib qho tseem ceeb rau kev tswj hwm tom qab neurosurgical meningitis, tab sis cov ntaub ntawv hais txog nws nkag mus thoob plaws ntshav - hlwb barrier (BBB) tsis txaus.
Pom zoo:
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