Video: Yam dab tsi tuaj yeem cuam tshuam cov tshuaj metabolism hauv cov neeg laus?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2024-01-18 09:28
Cov no suav nrog kev hloov pauv loj hauv lub cev muaj pes tsawg leeg thiab kev poob qis hauv lub raum ua haujlwm, ob qho tib si tuaj yeem cuam tshuam rau ntawm pharmacokinetics thiab pharmacodynamics ntawm cov tshuaj siv nyob rau hauv laus dua neeg (1,2).
Abstract
- kev laus .
- vascular khiav.
- tshem tawm cov tshuaj hepatic.
- tshuaj metabolism.
- tsis muaj zog.
- comorbidity.
- cov enzymes.
- noob neej.
Kuj nug, dab tsi cuam tshuam rau cov tshuaj metabolism hauv cov neeg laus thiab vim li cas?
Lwm yam yam ua tau thiab cawv lub siab metabolism ntawm tshuaj tau noj, suav nrog kev haus luam yeeb, txo qis ntshav khiav hauv cov neeg mob plawv tsis ua haujlwm, thiab noj tshuaj uas induce los yog inhibit cytochrome P-450 metabolic cov enzymes.
Tom qab ntawd, lo lus nug yog, dab tsi yog yam cuam tshuam rau cov tshuaj metabolism? Ntau yam physiological thiab pathological yam tseem tuaj yeem cuam tshuam cov tshuaj metabolism. Physiological yam uas tuaj yeem cuam tshuam cov tshuaj metabolism hauv suav nrog hnub nyoog , tus kheej kev hloov pauv (piv txwv li, pharmacogenetics), kev nkag mus hauv lub cev tsis zoo, khoom noj khoom haus, lub plab hnyuv, lossis poj niam deev sib txawv.
Tsuas yog li ntawd, vim li cas cov tshuaj txo qis rau cov neeg mob laus?
Txo cov tshuaj Kev tshem tawm tuaj yeem tshwm sim los ntawm kev poob qis hauv lub raum ua haujlwm nrog lub hnub nyoog, txawm tias tsis muaj kab mob raum [2]. Loj dua tshuaj reservoirs cia thiab txo clearance ntev tshuaj ib nrab-lub neej thiab ua rau kom ntshav nce ntxiv tshuaj concentration hauv cov neeg laus.
Cov kev hloov physiological dab tsi cuam tshuam rau cov tshuaj pharmacokinetics hauv cov neeg laus?
Pharmacokinetic hloov pauv suav nrog txo qis hauv lub raum thiab lub siab tshem tawm thiab nce qhov ntim ntawm kev faib tawm ntawm lipid soluble tshuaj (li no prolongation ntawm tshem tawm ib nrab-lub neej) whereas pharmacodynamic kev hloov koom nrog kev hloov pauv (feem ntau nce) rhiab heev rau ntau chav kawm ntawm tshuaj xws li anticoagulants,
Pom zoo:
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