Video: Kev laus cuam tshuam li cas cov tshuaj nqus cov metabolism hauv kev faib tawm thiab kev tso tawm?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Raws li hnub nyoog nce, kev ua haujlwm ntawm cov ntaub so ntswg thiab cov kabmob hauv lub cev maj mam poob. Vim qhov no poob ntawm lub cev ua haujlwm, kev nqus tshuaj , faib , metabolism thiab tso tawm (ADME txheej txheem) hauv cov laus neeg phem tshaj cov hluas.
Kuj tseem paub yog, hnub nyoog cuam tshuam li cas rau kev faib tshuaj?
Kev faib tshuaj yog cuam tshuam los ntawm kev hloov pauv hauv lub cev sib txuam nrog hnub nyoog . Cov nqaij ntshiv thiab cov nqaij mos tsawg zuj zus uas nrog rau kev laus yuav los cawv cov faib ntawm qhov tseeb tshuaj , zoo li yuav txo cov ntshav ntws mus rau cov ntaub so ntswg thiab lub cev. Active uptake mus rau hauv cov ntaub so ntswg kuj yuav cuam tshuam los ntawm kev laus.
Dab tsi cuam tshuam rau cov tshuaj metabolism hauv cov neeg laus? Lwm yam yam ua tau cawv lub siab metabolism ntawm tshuaj tau noj, suav nrog kev haus luam yeeb, txo qis ntshav khiav hauv cov neeg mob plawv tsis ua haujlwm, thiab noj tshuaj uas induce los yog inhibit cytochrome P-450 metabolic cov enzymes.
Ua li no, Absorption Distribution Metabolism Excretion yog dab tsi?
ADME yog ib qho luv luv hauv pharmacokinetics thiab pharmacology rau " nqus , faib , metabolism , thiab tso tawm ", thiab piav qhia txog qhov chaw ntawm cov tshuaj nyob rau hauv ib lub cev. Qee zaum, kev ywj pheej thiab / los yog toxicity kuj raug txiav txim siab, yielding LADME, ADMET, los yog LADMET.
Dab tsi yog qhov cuam tshuam ntawm kev laus ntawm lub raum tawm ntawm cov tshuaj?
Ib qho tseem ceeb tshaj plaws ntawm kev hloov pauv pharmacokinetic cuam tshuam nrog kev laus yog txo lub raum tshem tawm cov tshuaj . Tom qab hnub nyoog 40, creatinine ua tshem tawm txo qhov nruab nrab ntawm 8 mL / min / 1.73 m2/ xyoo caum; txawm li cas los xij, cov hnub nyoog -Txoj kev txo qis sib txawv ntawm ib tus neeg mus rau lwm tus.
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