Acetylcholinesterase inhibitor cuam tshuam li cas ntawm cov leeg nqaij?
Acetylcholinesterase inhibitor cuam tshuam li cas ntawm cov leeg nqaij?

Video: Acetylcholinesterase inhibitor cuam tshuam li cas ntawm cov leeg nqaij?

Video: Acetylcholinesterase inhibitor cuam tshuam li cas ntawm cov leeg nqaij?
Video: Acetylcholinesterases and Acetylcholinesterase Inhibitors Part 1 2024, Cuaj hlis
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Cov tsos mob hloov pauv hauv qhov hnyav. Acetylcholine yog ib tug neeg xa xov liaison uas nqa cov cim ntawm paj hlwb thiab cov leeg . Ib qho enzyme hu ua acetylcholinesterase tshuaj rhuav tshem acetylcholine. Cov no acetylcholinesterase inhibitors nce tus nqi ntawm acetylcholine muaj thiab yog li pab cov leeg activation thiab kev cog lus.

Ntawm no, yuav muaj dab tsi tshwm sim yog tias koj txwv tsis pub acetylcholinesterase?

Lub xub ntiag ntawm inhibiting cholinesterase tshuaj tiv thaiv kev tawg ntawm acetylcholine. Acetylcholine ua tau tom qab ntawd tsim kho, ua rau "jam" hauv lub paj hlwb. Yog tias acetylcholinesterase tsis muaj peev xwm ua kom tawg lossis tshem tawm acetylcholine, cov leeg ua tau mus txuas ntxiv mus uncontrollably.

Tsis tas li, AChE inhibitors ua haujlwm li cas? AChE cov tshuaj tiv thaiv kab mob los yog anti-cholinesterases inhibit Cov tshuaj cholinesterase enzyme los ntawm kev rhuav tshem ACh, ua rau ob qho tib si qib thiab sijhawm ntawm kev txiav txim siab cov neurotransmitter. Raws li hom kev nqis tes ua, AChE inhibitors tuaj yeem muab faib ua ob pawg: irreversible thiab thim rov qab.

Ib yam li ntawd, dab tsi yuav cuam tshuam rau AChE inhibitor ntawm cov hlab ntsha neuromuscular?

Acetylcholinesterase ( AChE ) inhibitors , suav nrog PB, tsim kev hloov pauv hloov pauv ntawm qhov neuromuscular hlws ris , qhov chaw ntawm kev sib txuas ntawm paj hlwb thiab cov leeg nqaij fibers, uas cov paj hlwb qhia cov leeg mus rau kev cog lus.

Ua li cas pepezil inhibit acetylcholinesterase?

Donepezil (C24H29TSIS YOG3, MW: 379.492) yog thim rov qab, xaiv AChE inhibitor tias yog tam sim no tau pom zoo rau cov tsos mob ntawm AD (Fig. 1A); nws yog ntseeg rau inhibit kev tawg ntawm cov neurotransmitter acetylcholine tshuaj (ACh) thiab them nyiaj rau qhov tsis txaus ntawm ACh hauv lub hlwb (Colovic li al., 2013).

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