Puas yog E coli raug rau novobiocin?

2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44

coli cov ua rau muaj kev nce ntxiv hauv kev raug mob rau novobiocin , inhibitor ntawm DNA topoisomerases. Qhov nce hauv novobiocin susceptibility yog piv rau cov efflux-deficient hlwb tab sis muaj ib tug txawv mechanism thiab ua nyob rau hauv synergy nrog efflux.

Ib sab ntawm no, puas yog E coli tiv taus novobiocin?

Feem ntau yog txheeb xyuas novobiocin tsis kam Kev hloov pauv yog nyob ntawm R136 thiab tau pom ntau yam kab mob (18, 40, 44), suav nrog E . coli cov (5, 13, 36, 39). Kev hloov pauv R136 los ntawm cysteine, histidine, leucine, thiab serine tau pom nyob hauv novobiocin - tiv taus E ..

Tsis tas li ntawd, E coli puas raug rau streptomycin? coli cov yog tiv taus rau > 1 tshuaj antimicrobial. Raws li qhov xav tau, qhov feem ntau tiv taus phenotypes yog rau cov tshuaj qub xws li tetracycline (40.9%) (nkag rau xyoo 1948), sulfonamide (36.2%) (nkag rau xyoo 1936), tshuaj streptomycin (34.2%) (qhia xyoo 1943), thiab ampicillin (24.1%) (qhia xyoo 1961).

Xav txog qhov no, E coli ua rau raug mob dab tsi?

E . coli cov Kev cais tawm tau nkag siab rau gentamicin, nitrofurantoin, ciprofloxacin thiab chloramphenicol. Hauv txoj kev tshawb no, norfloxacin, ciprofloxacin, gentamicin thiab chloramphenicol tau pom tias yog cov tshuaj tua kab mob zoo tshaj plaws tiv thaiv kab mob. E.

Puas yog Staphylococcus aureus raug rau novobiocin?

Txhua qhov cais tawm raug rau novobiocin , nfampicin, TMP/SMX, thiab vancomycin. Cuaj caum-xya cais tawm tau tiv taus clindamycin los ntawm disc diffusion method. Tag nrho 103 qhov sib cais ntawm methicillin- tiv taus Staph . aureus los ntawm xya lub koom haum sib txawv tau raug rau novobiocin ntawm ^0-25 mg/1 (Table I).