2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Hauv pharmacology, tshem tawm yog a pharmacokinetic ntsuas ntawm qhov ntim ntawm cov ntshav los ntawm qhov uas cov khoom raug tshem tawm tag nrho ib lub sijhawm. Qhov ntau qhia txog tus nqi ntawm kev tshem tawm cov tshuaj faib los ntawm plasma concentration.
Yog li ntawd, qhov tshem tawm ntawm cov tshuaj yog dab tsi?
Tshuaj tshem tawm muaj kev txhawj xeeb nrog tus nqi ntawm qhov active tshuaj raug tshem tawm ntawm lub cev; thiab rau feem ntau tshuaj nyob ruaj khov, tshem tawm tseem nyob tas li ntawd tshuaj input sib npaug tshuaj tso zis. Clearance yog txhais raws li tus nqi ntawm tshuaj tshem tawm faib los ntawm plasma concentration ntawm cov tshuaj.
Qhov thib ob, yam dab tsi cuam tshuam rau kev tshem tawm cov tshuaj? Ob qhov chaw tseem ceeb tshaj plaws rau tshuaj tshem tawm : lub raum thiab lub siab.
Lub raum tubular reabsorption tus nqi cuam tshuam los ntawm:
- pH.
- Tus nqi ntawm lub raum tubular tso zis.
- Cov kua qaub tsis muaj zog lossis cov tshuaj tsis muaj zog/tshuaj metabolite pKa piv rau cov zis pH.
Ib yam li ntawd, nws raug nug, qhov txawv ntawm kev tshem tawm thiab kev tshem tawm yog dab tsi?
Kev tshem tawm txhais tau tias yog 'qhov ntim ntawm cov ntshav tshem tawm ntawm cov tshuaj ib lub sijhawm'. Nws yog qhov sib npaug tsis tu ncua nruab nrab ntshav tshuaj concentration thiab tshem tawm tus nqi. Tshuaj tshem tawm tus nqi txhais tau tias yog 'tus nqi ntawm cov tshuaj tshem tawm ntawm cov ntshav hauv ib chav tsev lub sijhawm' Hauv xoom-qib kinetics, tshem tawm tus nqi yog qhov tas li.
Tus qauv rau kev tshem tawm yog dab tsi?
Kev soj ntsuam ntawm lub raum Function The tshem tawm cov khoom x (Cx) tuaj yeem suav ua Cx = Ax /P.x, qhov twg A.x yog tus nqi x tshem tawm los ntawm cov ntshav, P.x yog qhov nruab nrab ntshav siab, thiab C.x tau hais tawm hauv cov chav ntim ib lub sijhawm.
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