Video: Cov noob suppressor noob txhais li cas?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
A noob suppressor noob los yog anti-oncogene, yog a noob uas tswj hwm cov cell thaum lub sijhawm faib cell thiab rov ua dua. Thaum a qog suppressor gene yog mutated, nws ua rau poob lossis txo nws txoj haujlwm; ua ke nrog lwm yam caj kev hloov pauv no tuaj yeem ua rau lub cell loj hlob txawv txav.
Ua qhov no hauv kev txiav txim siab, cov qog nqaij hlav qog ua dab tsi?
Tumor suppressor noob yog li qub noob uas ua kom qeeb ntawm cell faib, kho DNA yuam kev, lossis qhia cov hlwb thaum yuav tuag (ib txoj kev hu ua apoptosis lossis programmed cell tuag). Thaum twg qog suppressor noob tsis ua haujlwm zoo, cov cell ua tau loj hlob ntawm kev tswj, uas ua tau coj mus rau mob qog noj ntshav.
Tsis tas li ntawd, yuav ua li cas tshwm sim thaum lub qog suppressor noob hloov? Yog ib noob suppressor noob tau hloov pauv , cov protein encoded los ntawm nws yog qhov tsis xws luag thiab tso cai rau kev faib cell thaum nws tsis tas yuav tshwm sim. Mutational inactivation ntawm p53 tso cai rau cov hlwb sib faib los ntawm kev tshem cov brakes ntawm cell proliferation.
Tsis tas li, dab tsi yog cov piv txwv ntawm cov qog suppressor noob?
Piv txwv ntawm qog suppressor noob yog BRCA1/BRCA2 noob , lwm yam hu ua "mob qog noj ntshav mis noob "Cov neeg uas muaj kev hloov pauv hauv ib qho ntawm cov no noob muaj kev pheej hmoo ntawm kev mob qog noj ntshav mis (nrog rau lwm cov qog nqaij hlav).
Yuav ua li cas cov qog suppressor noob ua rau mob qog noj ntshav?
Tumor suppressor noob Thaum ua haujlwm zoo, lawv khaws cov txheej txheem ntawm kev loj hlob ntawm tes thiab kev tuag ntawm tes (apoptosis) hauv kev kuaj xyuas. Los ntawm cov txheej txheem no, lawv ua tau kuj suppress qog kev loj hlob. Thaum a qog suppressor gene yog mutated, qhov no ua tau coj mus rau qog tsim los yog kev loj hlob.
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