Video: Dab tsi yog 2/3 DPG oxygen dissociation nkhaus?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
2, 3 - BPG Ua raws li heteroallosteric effector ntawm hemoglobin, txo qis hemoglobin txoj kev sib raug zoo rau cov pa los ntawm kev khi tshwj xeeb rau deoxyhemoglobin. Ib qho ntxiv concentration ntawm BPG Hauv cov qe ntshav liab txhawb kev tsim T, qis qis hauv lub xeev ntawm hemoglobin thiab yog li cov pa - khi nkhaus yuav hloov mus rau sab xis.
Xav txog qhov no, lub luag haujlwm ntawm 2/3 DPG yog dab tsi?
thauj cov pa oxygen hauv cov ntshav …… cov ntshav), carbon dioxide, thiab 2 , 3 - diphosphoglycerate tshuaj ( 2 , 3 - DPG ; ntsev hauv cov qe ntshav liab uas ua si a lub luag hauj lwm nyob rau hauv liberating oxygen los ntawm hemoglobin nyob rau hauv lub peripheral ncig). Cov tshuaj no tsis khi rau hemoglobin ntawm qhov chaw oxygen-binding.
Kuj Paub, yuav ua li cas 2/3 DPG tsim tawm? 2 , 3 - Diphosphoglycerate ( 2 , 3 - DPG ) yog qhov tshwj xeeb nruab nrab ntawm glycolysis hauv erythrocytes uas tau siv sai hauv cov xwm txheej ntawm cov pa oxygen ib txwm muaj. Txawm li cas los xij, thaum hypoxia ntsib nyob rau hauv cov ntaub so ntswg peripheral, qhov concentration ntawm 2 , 3 - DPG tuaj yeem sib sau mus rau qib tseem ceeb hauv teev.
Ua kom pom qhov no, dab tsi yog DPG cov pa sib cais sib cais?
OXY-HB DISSOCIATION CURVE -> ib feem loj ntawm qhov sib txawv ntawm cov ntshav thiab cov roj alveolar thaum feem ntau cov pa tau raug xa mus (diffusion hastened). Nruab nrab, qis qis qis ntawm nkhaus . -> cov ntaub so ntswg peripheral tuaj yeem thim ntau O2 rau me me hauv PO2 (pab O2 diffusion rau hauv cov ntaub so ntswg).
Dab tsi yog qhov cuam tshuam ntawm 2/3 bpg ntawm kev khi cov pa oxygen rau hemoglobin?
Ntawd yog, los ntawm khi rau hemoglobin cov , 2 , 3 - BPG txo hemoglobins affinity rau cov pa yog li hloov tag nrho cov pa - khi nkhaus mus rau sab xis. Nov yog qhov uas tso cai rau hemoglobin cov los ua kom muaj txiaj ntsig cov pa cov cab kuj nyob rau hauv lub cev, unloading txog 66% ntawm cov pa mus siv cov ntaub so ntswg.
Pom zoo:
4 yam nkhaus nkhaus ntawm tus nqaj qaum yog dab tsi?
Cov pob txha no, hu ua vertebrae, tau muab faib ua tsib thaj chaw: ncauj tsev menyuam, thoracic, lumbar, sacral, thiab coccyx. Txawm hais tias tus nqaj qaum ua rau peb sawv ntsug ncaj, tus qauv yog dab tsi tab sis. Muaj tiag peb qhov nkhaus nkhaus ntawm tus nqaj qaum (plaub yog tias koj suav tus pob tw)
Dab tsi ua rau oxyhemoglobin dissociation nkhaus hloov?
Kev nce siab ntxiv ntawm BPG hauv cov qe ntshav liab nyiam qhov tsim ntawm T, qis qis hauv lub xeev ntawm hemoglobin thiab yog li cov pa nkev-khi nkhaus yuav hloov mus rau sab xis
Dab tsi yog qhov oxyhemoglobin dissociation nkhaus qhia peb?
Hauv nws daim ntawv yooj yim tshaj plaws, txoj kab kev sib cais ntawm oxyhemoglobin piav qhia qhov sib piv ntawm ib nrab ntawm cov pa (x axis) thiab cov pa saturation (y axis). Hemoglobin kev sib raug zoo rau cov pa oxygen nce ntxiv raws li cov txheej txheem txuas ntxiv ntawm cov pa oxygen khi
Dab tsi cuam tshuam rau oxygen hemoglobin saturation dissociation nkhaus?
Thaum muaj cov pa roj carbon dioxide yaj, pH ntawm cov ntshav hloov pauv; qhov no ua rau lwm qhov hloov pauv hauv cov duab ntawm hemoglobin, uas ua rau nws muaj peev xwm khi cov pa roj carbon dioxide thiab txo nws lub peev xwm los khi cov pa oxygen
Dab tsi ua rau cov pa oxygen dissociation nkhaus hloov mus rau sab xis?
Qhov nce ntawm qhov kub hloov pauv qhov nkhaus mus rau sab xis, thaum qhov ntsuas kub poob qis hloov txoj kab nkhaus mus rau sab laug. Ua kom qhov kub thiab txias denatures kev sib raug zoo ntawm oxygen thiab hemoglobin, uas ua rau kom cov pa oxygen thiab hemoglobin thiab txo cov concentration ntawm oxyhaemoglobin