Cov txheej txheem:
Video: Dab tsi cuam tshuam rau oxygen hemoglobin saturation dissociation nkhaus?
2024 Tus sau: Michael Samuels | [email protected]. Kawg hloov kho: 2023-12-16 01:44
Thaum muaj cov pa roj carbon dioxide yaj, pH ntawm cov ntshav hloov; qhov no ua rau lwm qhov kev hloov pauv hauv cov duab hemoglobin , uas ua rau nws muaj peev xwm khi cov pa roj carbon dioxide thiab txo nws lub peev xwm los khi oxygen.
Ua li no, cov xwm txheej twg yuav ua rau cov pa oxygen hemoglobin saturation nkhaus mus rau sab laug?
Cov oxygen – hemoglobin dissociation nkhaus tuaj yeem raug tshem tawm xws li qhov kev sib raug zoo rau oxygen yog hloov. Yam uas ua haujlwm cov nkhaus suav nrog kev hloov pauv ntawm cov pa roj carbon dioxide concentration, cov ntshav kub, ntshav pH, thiab qhov siab ntawm 2, 3-diphosphoglycerate (2, 3-DPG).
Ib yam li ntawd, po2 cuam tshuam li cas rau hemoglobin saturation? Anatomy. Raws li cov PO 2 txo qis, feem pua ntawm saturated hemoglobin kuj txo. Cov pa oxygen- tshem tawm hemoglobin nkhaus muaj cov duab sigmoidal vim yog qhov xwm txheej ntawm hemoglobin . Nrog txhua cov pa oxygen molecule khi, hemoglobin undergoes ib tug conformational kev hloov pauv kom tso cai rau cov oxygen tom qab khi.
Tom qab ntawd, lo lus nug yog, yam dab tsi cuam tshuam rau hemoglobin kev sib raug zoo rau oxygen?
Cov teeb meem hauv lub cev hauv qab no cuam tshuam txog kev sib raug zoo ntawm hemoglobin rau oxygen:
- Lub siab ib nrab ntawm CO2 Ua kom CO2 hloov nkhaus mus rau sab xis.
- pH, ywj siab ntawm CO2
- Qhov siab ntawm 2, 3-DPG sab hauv erythrocytes.
- Lub xub ntiag ntawm txawv hom hemoglobin.
- Kub.
Yuav ua li cas co cuam tshuam rau oxygen hemoglobin dissociation nkhaus?
Cov pa roj carbon monoxide muaj 210 npaug ntau dua affinity rau hemoglobin tshaj oxygen 1. Tom qab lub carbon monoxide tau xaiv khi rau hemoglobin cov oxygen - hemoglobin dissociation nkhaus ntawm qhov seem oxyhaemoglobin hloov mus rau sab laug, txo oxygen tso tawm (Daim duab 1).
Pom zoo:
Dab tsi ua rau oxyhemoglobin dissociation nkhaus hloov?
Kev nce siab ntxiv ntawm BPG hauv cov qe ntshav liab nyiam qhov tsim ntawm T, qis qis hauv lub xeev ntawm hemoglobin thiab yog li cov pa nkev-khi nkhaus yuav hloov mus rau sab xis
Dab tsi yog 2/3 DPG oxygen dissociation nkhaus?
2,3-BPG ua raws li heteroallosteric effector hemoglobin, txo qis hemoglobin kev sib raug zoo rau cov pa oxygen los ntawm kev khi tshwj xeeb rau deoxyhemoglobin. Kev nce siab ntxiv ntawm BPG hauv cov qe ntshav liab nyiam qhov tsim ntawm T, qis qis hauv lub xeev ntawm hemoglobin thiab yog li cov pa nkev-khi nkhaus yuav hloov mus rau sab xis
Qhov kev hloov pauv twg yuav ua rau hloov mus rau sab laug hauv cov pa oxygen hemoglobin khi nkhaus?
Cov pa -hemoglobin kev sib cais sib cais tuaj yeem txav chaw xws li qhov kev sib raug zoo rau cov pa oxygen tau hloov pauv. Cov yam ntxwv uas hloov qhov nkhaus muaj xws li kev hloov pauv hauv cov pa roj carbon dioxide concentration, ntshav kub, ntshav pH, thiab cov concentration ntawm 2,3-diphosphoglycerate (2,3-DPG)
Dab tsi cuam tshuam rau oxygen khi rau hemoglobin?
Cov pa roj carbon dioxide qib, ntshav pH, lub cev kub, ib puag ncig, thiab cov kab mob tuaj yeem cuam tshuam rau oxygen lub peev xwm nqa thiab xa khoom. Kev txo qis hauv cov pa oxygen muaj peev xwm ntawm hemoglobin tau pom nrog kev nce hauv cov pa roj carbon dioxide thiab qhov kub, nrog rau txo qis hauv pH hauv lub cev
Dab tsi ua rau cov pa oxygen dissociation nkhaus hloov mus rau sab xis?
Qhov nce ntawm qhov kub hloov pauv qhov nkhaus mus rau sab xis, thaum qhov ntsuas kub poob qis hloov txoj kab nkhaus mus rau sab laug. Ua kom qhov kub thiab txias denatures kev sib raug zoo ntawm oxygen thiab hemoglobin, uas ua rau kom cov pa oxygen thiab hemoglobin thiab txo cov concentration ntawm oxyhaemoglobin